RNA-binding protein FUS

FUS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LA6, 2LCW, 4FDD, 4FQ3
Identifiers
Aliases	FUS, ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS, FUS RNA binding protein, altFUS
External IDs	OMIM: 137070; MGI: 1353633; GeneCards: FUS; OMA:FUS - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,191,605 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,584,873 bp
RNA expression pattern
	Top expressed in
	right testis; ; ventricular zone; ; right hemisphere of cerebellum; ; left testis; ; ganglionic eminence; ; right uterine tube; ; right ovary; ; left ovary; ; right lobe of thyroid gland; ; body of uterus;
	Top expressed in
	somite; ; ventricular zone; ; neural layer of retina; ; otic placode; ; mandibular prominence; ; Gonadal ridge; ; molar; ; abdominal wall; ; migratory enteric neural crest cell; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription coactivator activity; metal ion binding; retinoid X receptor binding; thyroid hormone receptor binding; myosin V binding; protein binding; identical protein binding; nucleic acid binding; ionotropic glutamate receptor binding; estrogen receptor binding; RNA binding; chromatin binding;
Cellular component	cytoplasm; polysome; perikaryon; dendritic spine; nucleoplasm; neuronal cell body; dendrite; dendritic spine head; perinuclear region of cytoplasm; nucleus;
Biological process	cellular response to calcium ion; mRNA splicing, via spliceosome; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; RNA splicing; regulation of RNA splicing; protein homooligomerization; positive regulation of nucleic acid-templated transcription; positive regulation of double-strand break repair via homologous recombination;
	Sources:Amigo / QuickGO
Orthologs
	2521
	233908
	ENSG00000089280
	ENSMUSG00000030795
	P35637
	P56959
	NM_001010850; NM_001170634; NM_001170937; NM_004960
	NM_139149; NM_001347649
	NP_001164105; NP_001164408; NP_004951
	NP_001334578; NP_631888
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein fused in sarcoma/translocated in liposarcoma (FUS/TLS), also known as heterogeneous nuclear ribonucleoprotein P2 is a protein that in humans is encoded by the FUS gene.^[5]^[6]^[7]^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000089280 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030795 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Eneroth M, Mandahl N, Heim S, Willén H, Rydholm A, Alberts KA, Mitelman F (Aug 1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2". Cancer Genet Cytogenet. 48 (1): 101–7. doi:10.1016/0165-4608(90)90222-V. PMID 2372777.
^ Rabbitts TH, Forster A, Larson R, Nathan P (Sep 1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811. S2CID 5964293.
^ Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES (December 1994). "TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain". Oncogene. 9 (12): 3717–29. PMID 7970732.
^ "Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)".
^ Crozat A, Aman P, Mandahl N, Ron D (June 1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature. 363 (6430): 640–4. Bibcode:1993Natur.363..640C. doi:10.1038/363640a0. PMID 8510758. S2CID 4358184.
^ Mrózek K, Karakousis CP, Bloomfield CD (April 1993). "Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3". Cancer Res. 53 (7): 1670–5. PMID 8453640.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089280 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030795 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2372777-5] Eneroth M, Mandahl N, Heim S, Willén H, Rydholm A, Alberts KA, Mitelman F (Aug 1990). "Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2". Cancer Genet Cytogenet. 48 (1): 101–7. doi:10.1016/0165-4608(90)90222-V. PMID 2372777.

[pmid7503811-6] Rabbitts TH, Forster A, Larson R, Nathan P (Sep 1993). "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma". Nat Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811. S2CID 5964293.

[pmid7970732-7] Prasad DD, Ouchida M, Lee L, Rao VN, Reddy ES (December 1994). "TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain". Oncogene. 9 (12): 3717–29. PMID 7970732.

[entrez-8] "Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)".

[pmid8510758-9] Crozat A, Aman P, Mandahl N, Ron D (June 1993). "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Nature. 363 (6430): 640–4. Bibcode:1993Natur.363..640C. doi:10.1038/363640a0. PMID 8510758. S2CID 4358184.

[pmid8453640-10] Mrózek K, Karakousis CP, Bloomfield CD (April 1993). "Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3". Cancer Res. 53 (7): 1670–5. PMID 8453640.

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