RNA silencing

RNA silencing or RNA interference refers to a family of gene silencing effects by which gene expression is negatively regulated by non-coding RNAs such as microRNAs. RNA silencing may also be defined as sequence-specific regulation of gene expression triggered by double-stranded RNA (dsRNA).[1] RNA silencing mechanisms are conserved among most eukaryotes.[2] The most common and well-studied example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the degradation of complementary messenger RNA. Other classes of small RNA have been identified, including piwi-interacting RNA (piRNA)[3] and its subspecies repeat associated small interfering RNA (rasiRNA).[4]

  1. ^ Cite error: The named reference Fire was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference pmid=15950871 was invoked but never defined (see the help page).
  3. ^ Monga I, Banerjee I (November 2019). "Computational Identification of piRNAs Using Features Based on RNA Sequence, Structure, Thermodynamic and Physicochemical Properties". Current Genomics. 20 (7): 508–518. doi:10.2174/1389202920666191129112705. PMC 7327968. PMID 32655289.
  4. ^ Cite error: The named reference Gunawardane was invoked but never defined (see the help page).