ROCK1

ROCK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML
Identifiers
Aliases	ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1
External IDs	OMIM: 601702; MGI: 107927; HomoloGene: 55899; GeneCards: ROCK1; OMA:ROCK1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.1 Start 20,946,906 bp[1] End 21,111,813 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 10,064,401 bp[2] End 10,182,045 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon popliteal artery tibial arteries monocyte right coronary artery bone marrow cells left coronary artery Descending thoracic aorta ascending aorta epithelium of colon Top expressed in tunica media of zone of aorta Rostral migratory stream zygote secondary oocyte ciliary body ascending aorta primary oocyte lacrimal gland aortic valve left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding tau protein binding tau-protein kinase activity Rho-dependent protein serine/threonine kinase activity Cellular component cytoplasm cytosol Golgi apparatus cell projection membrane ruffle Golgi membrane plasma membrane bleb centriole cytoskeleton lamellipodium extracellular region secretory granule lumen cytoplasmic stress granule amyloid-beta complex Biological process negative regulation of neuron apoptotic process leukocyte cell-cell adhesion smooth muscle contraction myoblast migration intracellular signal transduction regulation of actin cytoskeleton organization phosphorylation ephrin receptor signaling pathway bleb assembly negative regulation of protein binding regulation of actin filament-based process regulation of stress fiber assembly regulation of cell motility protein phosphorylation negative regulation of bicellular tight junction assembly vascular endothelial growth factor receptor signaling pathway regulation of cell adhesion Rho protein signal transduction membrane to membrane docking leukocyte tethering or rolling regulation of focal adhesion assembly negative regulation of angiogenesis regulation of keratinocyte differentiation positive regulation of focal adhesion assembly negative regulation of myosin-light-chain-phosphatase activity I-kappaB kinase/NF-kappaB signaling regulation of establishment of cell polarity cortical actin cytoskeleton organization apical constriction regulation of establishment of endothelial barrier actin cytoskeleton organization leukocyte migration signal transduction regulation of cytoskeleton organization apoptotic process neutrophil degranulation execution phase of apoptosis protein localization to plasma membrane G protein-coupled receptor signaling pathway aortic valve morphogenesis regulation of autophagy positive regulation of autophagy positive regulation of cardiac muscle hypertrophy positive regulation of gene expression peptidyl-serine phosphorylation neuron projection development positive regulation of MAPK cascade regulation of neuron differentiation negative regulation of membrane protein ectodomain proteolysis negative regulation of biomineral tissue development response to transforming growth factor beta regulation of angiotensin-activated signaling pathway neuron projection arborization positive regulation of amyloid-beta clearance regulation of synaptic vesicle endocytosis regulation of amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amyloid precursor protein catabolic process positive regulation of connective tissue replacement response to angiotensin mRNA destabilization blood vessel diameter maintenance mitotic cytokinesis peptidyl-threonine phosphorylation actomyosin structure organization embryonic morphogenesis regulation of cell junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6093 19877 Ensembl ENSG00000067900 ENSMUSG00000024290 UniProt Q13464 P70335 RefSeq (mRNA) NM_005406 NM_009071 RefSeq (protein) NP_005397 NP_033097 Location (UCSC) Chr 18: 20.95 – 21.11 Mb Chr 18: 10.06 – 10.18 Mb PubMed search [3] [4]
Wikidata
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ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation.^[5] ROCK1 plays a role in cancer and in particular cell motility, metastasis, and angiogenesis.^[5]