RRAD (gene)

RRAD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DPX, 2GJS, 3Q72, 3Q7P, 3Q7Q
Identifiers
Aliases	RRAD, RAD, RAD1, REM3, Ras related glycolysis inhibitor and calcium channel regulator
External IDs	OMIM: 179503; MGI: 1930943; HomoloGene: 3071; GeneCards: RRAD; OMA:RRAD - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,925,536 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,357,959 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; apex of heart; ; gastrocnemius muscle; ; bronchial epithelial cell; ; right auricle; ; triceps brachii muscle; ; muscle of thigh; ; left ventricle;
	Top expressed in
	right ventricle; ; endocardial cushion; ; interventricular septum; ; cardiac muscle tissue of left ventricle; ; atrioventricular valve; ; ascending aorta; ; atrium; ; tunica media of zone of aorta; ; aortic valve; ; blastocyst;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; calmodulin binding; GTPase activity; calcium channel regulator activity;
Cellular component	plasma membrane; membrane; intracellular anatomical structure;
Biological process	signal transduction; small GTPase mediated signal transduction; regulation of high voltage-gated calcium channel activity; negative regulation of high voltage-gated calcium channel activity;
	Sources:Amigo / QuickGO
Orthologs
	6236
	56437
	ENSG00000166592
	ENSMUSG00000031880
	P55042
	O88667
	NM_004165; NM_001128850
	NM_019662
	NP_001122322; NP_004156
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ras Related Glycolysis Inhibitor and Calcium Channel Regulator (RRAD) is a protein that in humans is encoded by the RRAD gene.^[5]^[6] RRAD is a Ras-related small GTPase that is regulated by p53 and plays a role in the regulation of aerobic glycolysis.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166592 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031880 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS (March 1995). "Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q". Diabetes. 44 (2): 243–7. doi:10.2337/diabetes.44.2.243. PMID 7859947.
^ "Entrez Gene: RRAD Ras-related associated with diabetes".
^ Zhang, Cen (2014). "Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD". Oncotarget. 4 (14): 5535–5546. doi:10.18632/oncotarget.2137. PMC 4170611. PMID 25114038.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166592 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031880 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7859947-5] Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS (March 1995). "Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q". Diabetes. 44 (2): 243–7. doi:10.2337/diabetes.44.2.243. PMID 7859947.

[entrez-6] "Entrez Gene: RRAD Ras-related associated with diabetes".

[7] Zhang, Cen (2014). "Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD". Oncotarget. 4 (14): 5535–5546. doi:10.18632/oncotarget.2137. PMC 4170611. PMID 25114038.

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