RRM2B

RRM2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VUX, 3HF1, 4DJN
Identifiers
Aliases	RRM2B, MTDPS8A, MTDPS8B, P53R2, ribonucleotide reductase regulatory TP53 inducible subunit M2B, RCDFRD
External IDs	OMIM: 604712; MGI: 2155865; HomoloGene: 56723; GeneCards: RRM2B; OMA:RRM2B - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	102,238,961 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	37,961,562 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; deltoid muscle; ; islet of Langerhans; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; germinal epithelium; ; tibialis anterior muscle; ; Skeletal muscle tissue of rectus abdominis; ; palpebral conjunctiva; ; pars reticulata;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; cardiac muscle tissue of left ventricle; ; Rostral migratory stream; ; sciatic nerve; ; cingulate gyrus; ; substantia nigra; ; habenula; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; oxidoreductase activity; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor;
Cellular component	mitochondrion; nucleus; nucleoplasm; cytoplasm; cytosol; ribonucleoside-diphosphate reductase complex;
Biological process	deoxyribonucleoside triphosphate metabolic process; renal system process; kidney development; response to oxidative stress; mitochondrial DNA replication; cellular response to DNA damage stimulus; deoxyribonucleotide biosynthetic process; DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; response to amine; DNA repair; nucleobase-containing small molecule interconversion;
	Sources:Amigo / QuickGO
Orthologs
	50484
	382985
	ENSG00000048392
	ENSMUSG00000022292
	Q7LG56
	Q6PEE3
	NM_015713; NM_001172477; NM_001172478
	NM_199476; NM_001357022; NM_001357023
	NP_001165948; NP_001165949; NP_056528
	NP_955770; NP_001343951; NP_001343952
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonucleotide-diphosphate reductase subunit M2 B is an enzyme that in humans is encoded by the RRM2B gene.^[5]^[6]^[7]^[8] The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000048392 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022292 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y (March 2000). "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage". Nature. 404 (6773): 42–9. Bibcode:2000Natur.404...42T. doi:10.1038/35003506. PMID 10716435. S2CID 4327888.
^ Nakano K, Bálint E, Ashcroft M, Vousden KH (August 2000). "A ribonucleotide reductase gene is a transcriptional target of p53 and p73". Oncogene. 19 (37): 4283–9. doi:10.1038/sj.onc.1203774. PMID 10980602.
^ Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chrétien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rötig A (June 2007). "Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion". Nature Genetics. 39 (6): 776–80. doi:10.1038/ng2040. PMID 17486094. S2CID 22103978.
^ "Entrez Gene: RRM2B ribonucleotide reductase M2 B (TP53 inducible)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048392 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022292 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10716435-5] Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y (March 2000). "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage". Nature. 404 (6773): 42–9. Bibcode:2000Natur.404...42T. doi:10.1038/35003506. PMID 10716435. S2CID 4327888.

[pmid10980602-6] Nakano K, Bálint E, Ashcroft M, Vousden KH (August 2000). "A ribonucleotide reductase gene is a transcriptional target of p53 and p73". Oncogene. 19 (37): 4283–9. doi:10.1038/sj.onc.1203774. PMID 10980602.

[pmid17486094-7] Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chrétien D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y, Munnich A, Rötig A (June 2007). "Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion". Nature Genetics. 39 (6): 776–80. doi:10.1038/ng2040. PMID 17486094. S2CID 22103978.

[entrez-8] "Entrez Gene: RRM2B ribonucleotide reductase M2 B (TP53 inducible)".

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