RTN2

RTN2
Identifiers
Aliases	RTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2
External IDs	OMIM: 603183; MGI: 107612; HomoloGene: 32180; GeneCards: RTN2; OMA:RTN2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,497,055 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,030,085 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; gastrocnemius muscle; ; vastus lateralis muscle; ; thoracic diaphragm; ; triceps brachii muscle; ; biceps brachii; ; glutes; ; body of tongue; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	triceps brachii muscle; ; muscle of thigh; ; temporal muscle; ; sternocleidomastoid muscle; ; ankle; ; digastric muscle; ; extensor digitorum longus muscle; ; vastus lateralis muscle; ; medial head of gastrocnemius muscle; ; tibialis anterior muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; T-tubule; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; terminal cisterna;
Biological process	intracellular protein transmembrane transport; regulation of glucose import;
	Sources:Amigo / QuickGO
Orthologs
	6253
	20167
	ENSG00000125744
	ENSMUSG00000030401
	O75298; Q96CG9
	O70622
	NM_206902; NM_005619; NM_206900; NM_206901
	NM_001025364; NM_013648
	NP_005610; NP_996783; NP_996784
	NP_001020535; NP_038676
	Wikidata
View/Edit Human	View/Edit Mouse

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.^[5]^[6]^[7]

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125744 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030401 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome". Genomics. 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484.
^ Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome. 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622. S2CID 7091637.
^ ^a ^b "Entrez Gene: RTN2 reticulon 2".