Rad50

RAD50
Identifiers
Aliases	RAD50, NBSLD, RAD502, hRad50, Rad50, RAD50 double strand break repair protein
External IDs	OMIM: 604040, 613078; MGI: 109292; HomoloGene: 38092; GeneCards: RAD50; OMA:RAD50 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	132,646,349 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	53,598,146 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; Achilles tendon; ; epithelium of colon; ; testicle; ; gonad; ; islet of Langerhans; ; stromal cell of endometrium; ; ventricular zone; ; tonsil; ; sural nerve;
	Top expressed in
	tail of embryo; ; genital tubercle; ; zygote; ; primary oocyte; ; secondary oocyte; ; internal carotid artery; ; Ileal epithelium; ; epiblast; ; Paneth cell; ; ovary;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein-macromolecule adaptor activity; nucleotide binding; DNA helicase activity; metal ion binding; single-stranded DNA endodeoxyribonuclease activity; ATPase activity; protein binding; 3'-5' exonuclease activity; hydrolase activity; ATP binding; double-stranded telomeric DNA binding; adenylate kinase activity; G-quadruplex DNA binding; single-stranded telomeric DNA binding;
Cellular component	site of double-strand break; membrane; nucleoplasm; chromosome; telomere; nucleus; condensed nuclear chromosome; Mre11 complex;
Biological process	reciprocal meiotic recombination; DNA recombination; telomere maintenance via telomerase; positive regulation of kinase activity; telomeric 3' overhang formation; cellular response to DNA damage stimulus; positive regulation of telomere maintenance; negative regulation of telomere capping; DNA duplex unwinding; meiosis; double-strand break repair; positive regulation of protein autophosphorylation; cell cycle; viral process; double-strand break repair via nonhomologous end joining; telomere maintenance; regulation of mitotic recombination; nucleic acid phosphodiester bond hydrolysis; DNA replication; DNA double-strand break processing; telomere maintenance via recombination; DNA synthesis involved in DNA repair; chromosome organization involved in meiotic cell cycle; regulation of signal transduction by p53 class mediator; nucleotide phosphorylation; DNA repair; double-strand break repair via homologous recombination; strand displacement; telomere capping; nucleoside monophosphate phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	10111
	19360
	ENSG00000113522
	ENSMUSG00000020380
	Q92878
	P70388
	NM_133482; NM_005732
	NM_009012
	NP_005723
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113522 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020380 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAD50 RAD50 homolog (S. cerevisiae)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113522 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020380 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAD50 RAD50 homolog (S. cerevisiae)".

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