Rage syndrome

Rage syndrome
Other namesA22, episodic dyscontrol, stimulus-responsive psychomotor epilepsy, Mental lapse aggression syndrome
A happy Belgian Malinois interacting with their handler. As a military working dog bred for and trained to utilize aggression, they wear a "DO NOT PET" patch on their collar. Their handler looks into their eyes.
The Malinois was the first breed to have a specific genetic polymorphism linked to rage syndrome.
SpecialtyNeurology
Symptoms
ComplicationsBehavioral euthanasia
Usual onset1–3 years old
DurationLifelong
CausesUnknown
Risk factorsPolyA(22) (in Malinois), DAT-VNTR (in Malinois), likely other genetic factors, breed, other seizures
Diagnostic methodEEG, with complete exclusion of other medical conditions via thorough medical testing
Differential diagnosisAny untreated illness (Pathophysiological aggression) or behavioral condition
PreventionSelective breeding, Health testing (PolyA(22) test, in Malinois)
ManagementAnticonvulsants, muzzling, barrier use, lifestyle changes
MedicationAntiepileptic drugs (Phenobarbital)
PrognosisGenerally poor

Rage syndrome is a rare seizure disorder in dogs, characterized by explosive aggression.[1][2][3]

It is frequently confused with idiopathic aggression, a term for aggression with no identifiable cause. Rage syndrome is most often a misdiagnosis of dogs with an unrelated, but more common, form of aggression. Although the scientific evidence is limited, it is thought to be genetic in origin, and is heritable.[4] It is treated with antiepileptics.[5]

  1. ^ Cite error: The named reference Beaver 1980 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Reisner 2005 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Amat 2009 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference Dodman 1992 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference Bowen 2005 was invoked but never defined (see the help page).