Clinical data | |
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Trade names | Isentress |
Other names | RAL |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608004 |
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Routes of administration | By mouth |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | 60% (FDA) |
Protein binding | 83% |
Metabolism | Liver (UGT1A1) |
Elimination half-life | 9 hours |
Excretion | feces and urine |
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KEGG | |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.124.631 |
Chemical and physical data | |
Formula | C20H21FN6O5 |
Molar mass | 444.423 g·mol−1 |
3D model (JSmol) | |
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Raltegravir, sold under the brand name Isentress, is an antiretroviral medication used, together with other medication, to treat HIV/AIDS.[5] It may also be used, as part of post exposure prophylaxis, to prevent HIV infection following potential exposure.[6] It is taken by mouth.[5]
Common side effects include trouble sleeping, feeling tired, nausea, high blood sugar, and headaches.[6] Severe side effects may include allergic reactions including Stevens–Johnson syndrome, muscle breakdown, and liver problems.[6] It is unclear if use during pregnancy or breastfeeding is safe.[6] Raltegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for viral replication.[6]
Raltegravir was approved for medical use in the United States in 2007.[6] It is on the World Health Organization's List of Essential Medicines.[7] Lamivudine/raltegravir, a combination with lamivudine, is also available.[6]