Ran (protein)

RAN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I2M, 1IBR, 1K5D, 1K5G, 1QBK, 1RRP, 2MMC, 2MMG, 3CH5, 3EA5, 3GJ0, 3GJ3, 3GJ4, 3GJ5, 3GJ6, 3GJ7, 3GJ8, 3GJX, 3NBY, 3NBZ, 3NC0, 3NC1, 3ZJY, 4C0Q, 4GMX, 4GPT, 4HAT, 4HAU, 4HAV, 4HAW, 4HAX, 4HAY, 4HAZ, 4HB0, 4HB2, 4HB3, 4HB4, 4OL0, 4WVF, 5CIQ, 5CIT, 5CIW, 5CJ2, 5CLL, 5CLQ, 5DH9, 5DHA, 5DHF, 5DI9, 5DIF, 3A6P, 1A2K, 5DIS, 5BXQ, 5DLQ, 5FYQ, 2N1B, 5JLJ
Identifiers
Aliases	RAN, ARA24, Gsp1, TC4, Ran, member RAS oncogene family
External IDs	OMIM: 601179; MGI: 1333112; HomoloGene: 68143; GeneCards: RAN; OMA:RAN - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.33 Start 130,872,037 bp[1] End 130,877,678 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,097,133 bp[2] End 129,101,387 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone ganglionic eminence right testis left testis stromal cell of endometrium right adrenal gland mucosa of transverse colon left adrenal gland left adrenal cortex Top expressed in embryo embryo ventricular zone otic placode otic vesicle yolk sac lens habenula neural tube arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transcription coactivator activity pre-miRNA binding chromatin binding protein binding androgen receptor binding GTPase activity GTP binding RNA binding cadherin binding magnesium ion binding structural constituent of nuclear pore GDP binding protein heterodimerization activity nuclear export signal receptor activity metal ion binding protein domain specific binding protein-containing complex binding dynein intermediate chain binding importin-alpha family protein binding Cellular component recycling endosome cytosol Flemming body melanosome nucleoplasm midbody RNA nuclear export complex nucleolus centriole chromatin extracellular exosome membrane cytoplasm nucleus extracellular matrix nuclear pore host cell nuclear envelope protein-containing complex male germ cell nucleus manchette sperm flagellum Biological process ribosomal small subunit export from nucleus intracellular transport of virus androgen receptor signaling pathway protein localization to nucleolus mitotic spindle organization DNA metabolic process pre-miRNA export from nucleus cell division positive regulation of transcription, DNA-templated nucleocytoplasmic transport protein export from nucleus protein transport ribosomal large subunit export from nucleus cell cycle positive regulation of protein binding viral process tRNA export from nucleus mitotic cell cycle protein import into nucleus miRNA metabolic process regulation of cholesterol biosynthetic process regulation of gene silencing by miRNA transport mitotic sister chromatid segregation GTP metabolic process snRNA import into nucleus positive regulation of protein import into nucleus spermatid development response to organic cyclic compound hippocampus development actin cytoskeleton organization regulation of protein binding cellular response to mineralocorticoid stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5901 19384 Ensembl ENSG00000132341 ENSMUSG00000029430 UniProt P62826 P62827 RefSeq (mRNA) NM_006325 NM_001300796 NM_001300797 NM_009391 RefSeq (protein) NP_001287725 NP_001287726 NP_006316 NP_033417 Location (UCSC) Chr 12: 130.87 – 130.88 Mb Chr 5: 129.1 – 129.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ran (RAs-related Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that is involved in transport into and out of the cell nucleus during interphase and also involved in mitosis. It is a member of the Ras superfamily.^[5][6][7]

Ran is a small G protein that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein has also been implicated in the control of DNA synthesis and cell cycle progression, as mutations in Ran have been found to disrupt DNA synthesis.^[8]