| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | Protective antigen of anthrax toxin |
| Clinical data | |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| Chemical and physical data | |
| Formula | C6320H9794N1702O1998S42 |
| Molar mass | 142934.31 g·mol−1 |
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Raxibacumab [2] is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.[3] In December 2012 raxibacumab was approved in the United States for the treatment of inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs, and for prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.[4][5]
The antibody was discovered in a joint venture between Cambridge Antibody Technology and Human Genome Sciences. Cambridge Antibody Technology discovered the antibody to Human Genome Sciences's target and, in 2012, HGS were purchased by GlaxoSmithKline (GSK).[6] In 2017, it was acquired by Emergent BioSolutions[7]
- ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
- ^ Mazumdar S (2009). "Raxibacumab". mAbs. 1 (6): 531–8. doi:10.4161/mabs.1.6.10195. PMC 2791309. PMID 20068396.
- ^ Migone TS, Subramanian GM, Zhong J, Healey LM, Corey A, Devalaraja M, et al. (July 2009). "Raxibacumab for the treatment of inhalational anthrax". The New England Journal of Medicine. 361 (2): 135–44. doi:10.1056/NEJMoa0810603. PMID 19587338.
- ^ "Approval Letter" (PDF). U.S. Food and Drug Administration.
- ^ Kummerfeldt CE (2014). "Raxibacumab: potential role in the treatment of inhalational anthrax". Infection and Drug Resistance. 7: 101–9. doi:10.2147/IDR.S47305. PMC 4011807. PMID 24812521.
- ^ "GSK completes acquisition of Human Genome Sciences". GlaxoSmithKline. 3 August 2012. Archived from the original on 2013-10-04. Retrieved 2013-10-05.
- ^ "Emergent BioSolutions Completes Acquisition of Raxibacumab, an FDA-Approved Anthrax Monoclonal Antibody, From GSK". 3 October 2017.