Relaxin

Relaxin 2
Relaxin 2
Identifiers
Symbol	RLN2
Alt. symbols	H2, RLXH2, bA12D24.1.1, bA12D24.1.2
NCBI gene	6019
HGNC	10027
OMIM	179740
PDB	6RLX
RefSeq	NM_134441
UniProt	P04090
Other data
Locus	Chr. 9 qter-q12
Structures
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Structures	Swiss-model
Domains	InterPro

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Structures	Swiss-model
Domains	InterPro

Relaxin 1
Relaxin 1
Identifiers
Symbol	RLN1
Alt. symbols	H1
NCBI gene	6013
HGNC	10026
OMIM	179730
RefSeq	NM_006911
UniProt	P04808
Other data
Locus	Chr. 9 qter-q12
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Relaxin 3

Identifiers

Symbol

RLN3

Alt. symbols

ZINS4, RXN3, H3

Other data

Chr. 19 p13.3

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Structures	Swiss-model
Domains	InterPro

Relaxin is a protein hormone of about 6000 Da,^[1] first described in 1926 by Frederick Hisaw.^[2]^[3]

The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (RLN3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, and INSL6 remain uncharacterised.^[4]^[5]

^ Bani D (January 1997). "Relaxin: a pleiotropic hormone". General Pharmacology. 28 (1): 13–22. doi:10.1016/s0306-3623(96)00171-1. PMID 9112071.
^ "If a Gopher Can Do It …". Time Magazine. 1944-04-10. Archived from the original on December 15, 2008. Retrieved 2009-05-20.
^ Becker GJ, Hewitson TD (March 2001). "Relaxin and renal fibrosis". Kidney International. 59 (3): 1184–5. doi:10.1046/j.1523-1755.2001.0590031184.x. PMID 11231378.
^ Wilkinson TN, Speed TP, Tregear GW, Bathgate RA (February 2005). "Evolution of the relaxin-like peptide family". BMC Evolutionary Biology. 5: 14. doi:10.1186/1471-2148-5-14. PMC 551602. PMID 15707501.
^ Patil NA, Rosengren KJ, Separovic F, Wade JD, Bathgate RA, Hossain MA (May 2017). "Relaxin family peptides: structure-activity relationship studies". British Journal of Pharmacology. 174 (10): 950–961. doi:10.1111/bph.13684. PMC 5406294. PMID 27922185.

[pmid9112071-1] Bani D (January 1997). "Relaxin: a pleiotropic hormone". General Pharmacology. 28 (1): 13–22. doi:10.1016/s0306-3623(96)00171-1. PMID 9112071.

[urlIf_a_Gopher_Can_Do_It_..._-_TIME-2] "If a Gopher Can Do It …". Time Magazine. 1944-04-10. Archived from the original on December 15, 2008. Retrieved 2009-05-20.

[pmid11231378-3] Becker GJ, Hewitson TD (March 2001). "Relaxin and renal fibrosis". Kidney International. 59 (3): 1184–5. doi:10.1046/j.1523-1755.2001.0590031184.x. PMID 11231378.

[pmid15707501-4] Wilkinson TN, Speed TP, Tregear GW, Bathgate RA (February 2005). "Evolution of the relaxin-like peptide family". BMC Evolutionary Biology. 5: 14. doi:10.1186/1471-2148-5-14. PMC 551602. PMID 15707501.

[5] Patil NA, Rosengren KJ, Separovic F, Wade JD, Bathgate RA, Hossain MA (May 2017). "Relaxin family peptides: structure-activity relationship studies". British Journal of Pharmacology. 174 (10): 950–961. doi:10.1111/bph.13684. PMC 5406294. PMID 27922185.

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