Relaxin family peptide hormones

See also: Insulin/IGF/Relaxin family
Relaxin 1
Identifiers
SymbolRLN1
Alt. symbolsH1
NCBI gene6013
HGNC10026
OMIM179730
RefSeqNM_006911
UniProtP04808
Other data
LocusChr. 9 qter-q12
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StructuresSwiss-model
DomainsInterPro
Relaxin 2
Identifiers
SymbolRLN2
Alt. symbolsH2, RLXH2, bA12D24.1.1, bA12D24.1.2
NCBI gene6019
HGNC10027
OMIM179740
PDB6RLX
RefSeqNM_134441
UniProtP04090
Other data
LocusChr. 9 qter-q12
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StructuresSwiss-model
DomainsInterPro
Relaxin 3
Identifiers
SymbolRLN3
Alt. symbolsZINS4, RXN3, H3
NCBI gene117579
HGNC17135
OMIM606855
RefSeqNM_080864
UniProtQ8WXF3
Other data
LocusChr. 19 p13.3
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DomainsInterPro
Insulin-like peptide 3
Identifiers
SymbolINSL3
Other data
LocusChr. 19 [1]
Insulin-like peptide 5
Identifiers
SymbolINSL5
Other data
LocusChr. 1 [2]

Relaxin family peptide hormones in humans are represented by seven members: three relaxin-like (RLN) and four insulin-like (INSL) peptides: RLN1, RLN2, RNL3, INSL3, INSL4, INSL5, INSL6. This subdivision into two classes (RLN and INSL) is based primarily on early findings,[1] and does not reflect the evolutionary origins or physiological differences between peptides.[2] For example, it is known that the genes coding for RLN3 and INSL5 arose from one ancestral gene, and INSL3 shares origin with RLN2 and its multiple duplicates: RLN1, INSL4, INSL6.[2]

  1. ^ Sherwood OD (April 2004). "Relaxin's physiological roles and other diverse actions". Endocrine Reviews. 25 (2): 205–234. doi:10.1210/er.2003-0013. PMID 15082520.
  2. ^ a b Yegorov S, Good S (2012). "Using paleogenomics to study the evolution of gene families: origin and duplication history of the relaxin family hormones and their receptors". PLOS ONE. 7 (3): e32923. Bibcode:2012PLoSO...732923Y. doi:10.1371/journal.pone.0032923. PMC 3310001. PMID 22470432.