Renin receptor

ATP6AP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LBS, 3LC8
Identifiers
Aliases	ATP6AP2, APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS, HT028, ATPase H+ transporting accessory protein 2, CDG2R
External IDs	OMIM: 300556; MGI: 1917745; HomoloGene: 38097; GeneCards: ATP6AP2; OMA:ATP6AP2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	40,606,848 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	12,483,288 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; tibia; ; germinal epithelium; ; parietal pleura; ; epithelium of nasopharynx; ; retinal pigment epithelium; ; mucosa of paranasal sinus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; renal medulla;
	Top expressed in
	Epithelium of choroid plexus; ; Paneth cell; ; ciliary body; ; iris; ; retinal pigment epithelium; ; conjunctival fornix; ; substantia nigra; ; medial dorsal nucleus; ; medial geniculate nucleus; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; enzyme binding; signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane; external side of plasma membrane; neuron projection; cell body; tertiary granule membrane; ficolin-1-rich granule membrane; extracellular space; apical plasma membrane;
Biological process	positive regulation of transforming growth factor beta1 production; rostrocaudal neural tube patterning; head morphogenesis; regulation of MAPK cascade; eye pigmentation; angiotensin maturation; positive regulation of Wnt signaling pathway; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	10159
	70495
	ENSG00000182220
	ENSMUSG00000031007
	O75787
	Q9CYN9
	NM_005765
	NM_027439
	NP_005756
	NP_081715
	Wikidata
View/Edit Human	View/Edit Mouse

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
^ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.
^ "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182220 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031007 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9556572-5] Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.

[pmid11590366-6] Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.

[entrez-7] "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".

[1]

[2]

[3]

[4]

[5]

[6]

[7]