Repaglinide

Repaglinide
Clinical data
Trade namesPrandin, Novonorm, Enyglid, others
AHFS/Drugs.comMonograph
MedlinePlusa600010
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability56% (oral)
Protein binding>98%
MetabolismLiver oxidation and glucuronidation (CYP3A4-mediated)
Elimination half-life1 hour
ExcretionFecal (90%) and kidney (8%)
Identifiers
  • (S)-2-Ethoxy-4-(1-[2-{piperidin-1-yl}phenyl]-3-methylbutylcarbamoylmethyl)benzoic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.158.190 Edit this at Wikidata
Chemical and physical data
FormulaC27H36N2O4
Molar mass452.595 g·mol−1
3D model (JSmol)
Melting point126 to 128 °C (259 to 262 °F)
  • O=C(O)c1ccc(cc1OCC)CC(=O)N[C@H](c2ccccc2N3CCCCC3)CC(C)C
  • InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1 checkY
  • Key:FAEKWTJYAYMJKF-QHCPKHFHSA-N checkY
  (verify)

Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is a medication used in addition to diet and exercise for blood sugar control in type 2 diabetes.[1] The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas; like other antidiabetic drugs, a main side effect concern is hypoglycemia.[1] It is sold by Novo Nordisk under the name of Prandin in the United States, Gluconorm in Canada, Surepost in Japan, Repaglinide in Egypt, and Novonorm elsewhere. In Japan it is produced by Dainippon Sumitomo Pharma.[2][failed verification]

  1. ^ a b "DailyMed - Repaglinide - repaglinide tablet". dailymed.nlm.nih.gov. Retrieved 2015-11-04.
  2. ^ "Welcome to Novo Nordisk A/S". Novo Nordisk A/S. Retrieved 2015-11-05.