Replication protein A1

RPA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EWI, 1FGU, 1JMC, 1L1O, 2B29, 2B3G, 4IJH, 4IJL, 4IPC, 4IPD, 4IPG, 4IPH, 4LUO, 4LUV, 4LUZ, 4LW1, 4LWC, 4NB3, 4O0A, 4R4C, 4R4I, 4R4O, 4R4Q, 4R4T, 5E7N, 5EAY
Identifiers
Aliases	RPA1, HSSB, MST075, REPA1, RF-A, RP-A, RPA70, Replication protein A1, PFBMFT6
External IDs	OMIM: 179835; MGI: 1915525; HomoloGene: 2208; GeneCards: RPA1; OMA:RPA1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	1,900,082 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	75,239,150 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; ventricular zone; ; ganglionic eminence; ; parietal pleura; ; visceral pleura; ; germinal epithelium; ; gingival epithelium; ; trabecular bone; ; tibia; ; parotid gland;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; retinal pigment epithelium; ; ciliary body; ; primitive streak; ; vestibular membrane of cochlear duct; ; iris; ; Epithelium of choroid plexus; ; abdominal wall; ; endothelial cell of lymphatic vessel; ; Paneth cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; single-stranded DNA binding; damaged DNA binding; protein binding; nucleic acid binding; G-rich strand telomeric DNA binding; single-stranded telomeric DNA binding; sequence-specific DNA binding;
Cellular component	PML body; nucleoplasm; DNA replication factor A complex; nucleus; site of DNA damage;
Biological process	DNA-dependent DNA replication; nucleotide-excision repair, DNA gap filling; DNA recombination; interstrand cross-link repair; error-free translesion synthesis; G1 phase; error-prone translesion synthesis; cellular response to DNA damage stimulus; DNA replication; regulation of cellular response to heat; DNA mismatch repair; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex stabilization; nucleotide-excision repair; DNA repair; base-excision repair; regulation of signal transduction by p53 class mediator; double-strand break repair via homologous recombination; nucleotide-excision repair, preincision complex assembly; protein localization to chromosome; telomere maintenance; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; DNA unwinding involved in DNA replication; telomere maintenance via telomerase; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	6117
	68275
	ENSG00000132383
	ENSMUSG00000000751
	P27694
	Q8VEE4
	NM_002945; NM_001355120; NM_001355121
	NM_001164223; NM_026653
	NP_002936; NP_001342049; NP_001342050
	NP_001157695; NP_080929
	Wikidata
View/Edit Human	View/Edit Mouse

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132383 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000751 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (April 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". J Biol Chem. 268 (9): 6131–8. doi:10.1016/S0021-9258(18)53229-4. PMID 8454588.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132383 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000751 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8454588-5] Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (April 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". J Biol Chem. 268 (9): 6131–8. doi:10.1016/S0021-9258(18)53229-4. PMID 8454588.

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