Replication protein A2

RPA2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DPU, 1L1O, 1QUQ, 1Z1D, 2PI2, 2PQA, 2Z6K, 3KDF, 4MQV, 4OU0
Identifiers
Aliases	RPA2, REPA2, RP-A p32, RP-A p34, RPA32, replication protein A2
External IDs	OMIM: 179836; MGI: 1339939; HomoloGene: 37712; GeneCards: RPA2; OMA:RPA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,914,746 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	132,506,063 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; granulocyte; ; ganglionic eminence; ; right testis; ; left testis; ; gastrocnemius muscle; ; Achilles tendon; ; right uterine tube; ; gonad; ; tibialis anterior muscle;
	Top expressed in
	somite; ; fetal liver hematopoietic progenitor cell; ; primitive streak; ; embryo; ; ventricular zone; ; mandibular prominence; ; endocardial cushion; ; abdominal wall; ; germ layer; ; ectoderm;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein N-terminus binding; single-stranded DNA binding; damaged DNA binding; protein binding; enzyme binding; protein phosphatase binding; ubiquitin protein ligase binding; G-rich strand telomeric DNA binding; double-stranded DNA binding; sequence-specific DNA binding;
Cellular component	site of double-strand break; PML body; nucleoplasm; telomere; DNA replication factor A complex; chromatin; nucleus; nuclear body; condensed nuclear chromosome;
Biological process	nucleotide-excision repair, DNA gap filling; DNA recombination; interstrand cross-link repair; regulation of double-strand break repair via homologous recombination; error-free translesion synthesis; G1 phase; error-prone translesion synthesis; cellular response to DNA damage stimulus; DNA replication; mitotic G1 DNA damage checkpoint signaling; regulation of DNA damage checkpoint; regulation of cellular response to heat; DNA mismatch repair; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; base-excision repair; nucleotide-excision repair; nucleotide-excision repair, preincision complex stabilization; regulation of signal transduction by p53 class mediator; DNA repair; double-strand break repair via homologous recombination; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, DNA incision, 3'-to lesion; protein localization to chromosome; telomere maintenance; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; telomere maintenance via recombination; DNA topological change; DNA unwinding involved in DNA replication; mitotic recombination; telomere maintenance via telomerase; reciprocal meiotic recombination; heteroduplex formation; positive regulation of helicase activity;
	Sources:Amigo / QuickGO
Orthologs
	6118
	19891
	ENSG00000117748
	ENSMUSG00000028884
	P15927
	Q62193
	NM_001286076; NM_001297558; NM_002946; NM_001355128; NM_001355129
	NM_011284
	NP_001273005; NP_001284487; NP_002937; NP_001342057; NP_001342058
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Replication protein A 32 kDa subunit is a protein that in humans is encoded by the RPA2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028884 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Mar 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". The Journal of Biological Chemistry. 268 (9): 6131–8. doi:10.1016/S0021-9258(18)53229-4. PMID 8454588.
^ "Entrez Gene: RPA2 Replication protein A2, 32kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000117748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028884 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8454588-5] Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (Mar 1993). "Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A". The Journal of Biological Chemistry. 268 (9): 6131–8. doi:10.1016/S0021-9258(18)53229-4. PMID 8454588.

[6] "Entrez Gene: RPA2 Replication protein A2, 32kDa".

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