Rescinnamine

Rescinnamine
Clinical data
Trade names	Moderil, Cinnasil, Anaprel
Other names	methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4(9),5,7-tetraene-19-carboxylate
Routes of; administration	By mouth
ATC code	C02AA01 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name methyl (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}yohimban-16-carboxylate;
CAS Number	24815-24-5 ;
PubChem CID	5280954;
IUPHAR/BPS	7098;
DrugBank	DB01180 ;
ChemSpider	4444446 ;
UNII	Q6W1F7DJ2D;
KEGG	D00198 ;
ChEBI	CHEBI:28572 ;
ChEMBL	ChEMBL1668 ;
CompTox Dashboard (EPA)	DTXSID3023554 ;
ECHA InfoCard	100.042.232
Chemical and physical data
Formula	C35H42N2O9
Molar mass	634.726 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [H][C@]26C[C@@H](OC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1)[C@H](OC)[C@@H](C(=O)OC)[C@@]2([H])C[C@]5([H])c4[nH]c3cc(OC)ccc3c4CCN5C6;
	InChI InChI=1S/C35H42N2O9/c1-40-21-8-9-22-23-11-12-37-18-20-15-29(46-30(38)10-7-19-13-27(41-2)33(43-4)28(14-19)42-3)34(44-5)31(35(39)45-6)24(20)17-26(37)32(23)36-25(22)16-21/h7-10,13-14,16,20,24,26,29,31,34,36H,11-12,15,17-18H2,1-6H3/b10-7+/t20-,24+,26-,29-,31+,34+/m1/s1 ; Key:SZLZWPPUNLXJEA-QEGASFHISA-N ;
	(verify)

Rescinnamine, known by the brand names Moderil, Cinnasil, and Anaprel, is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

It is an indoloquinolizine alkaloid similar to reserpine, obtained from Rauvolfia serpentina^[1] and other species of Rauvolfia.^[2]

^ FIFE R, MACLAURIN JC, WRIGHT JH (December 1960). "Rescinnamine in treatment of hypertension in hospital clinic and in general practice". British Medical Journal. 2 (5216): 1848–50. doi:10.1136/bmj.2.5216.1848. PMC 2098607. PMID 13699407.
^ Balsevich J, Constabel F, Kurz WG (1982). "Alkaloids of Vinca major cv. Variegata". Planta Med. 44 (2): 91–3. doi:10.1055/s-2007-971409. PMID 17402086.