Research in management of Ebola

This article is about current experimental treatments to fight the Ebola virus. For vaccine information, see Ebola vaccine.

Researcher working with the Ebola virus while wearing a BSL-4 positive pressure suit

There is a cure for the Ebola virus disease that is currently approved for market the US government has inventory in the Strategic National Stockpile.[1] For past and current Ebola epidemics, treatment has been primarily supportive in nature.[2]

As of August 2023, treatment known as atoltivimab/maftivimab/odesivimab and experimental ansuvimab were found to be 90% effective.[3][4][5][6]

In October 2020, the U.S. Food and Drug Administration (FDA) approved atoltivimab/maftivimab/odesivimab with an indication for the treatment of infection caused by Zaire ebolavirus.[7]

  1. ^ Choi JH, Croyle MA (December 2013). "Emerging targets and novel approaches to Ebola virus prophylaxis and treatment". BioDrugs. 27 (6): 565–83. doi:10.1007/s40259-013-0046-1. PMC 3833964. PMID 23813435.
  2. ^ Clark DV, Jahrling PB, Lawler JV (September 2012). "Clinical management of filovirus-infected patients". Viruses. 4 (9): 1668–86. doi:10.3390/v4091668. PMC 3499825. PMID 23170178.
  3. ^ McNeil Jr DG (12 August 2019). "A Cure for Ebola? Two New Treatments Prove Highly Effective in Congo". The New York Times. Retrieved 12 August 2019. The two new therapies were among four that were tested in a trial that has enrolled almost 700 patients since November. The two worked so well that a committee meeting on Friday to look at preliminary results in the first 499 patients immediately recommended that the other two treatments, ZMapp, made by Mapp Biopharmaceutical, and remdesivir, made by Gilead Sciences, be stopped. All patients will now be offered either the Regeneron or the Biotherapeutics drug.
  4. ^ Maxmen A (12 August 2019). "Two Ebola drugs show promise amid ongoing outbreak". Nature. doi:10.1038/d41586-019-02442-6. ISSN 0028-0836. PMID 32778704. S2CID 201975390.
  5. ^ Hoenen T, Groseth A, Feldmann H (24 July 2019). "Therapeutic strategies to target the Ebola virus life cycle". Nature Reviews. Microbiology. 17 (10): 593–606. doi:10.1038/s41579-019-0233-2. ISSN 1740-1526. PMID 31341272.
  6. ^ "Investigational Monoclonal Antibody to Treat Ebola Is Safe in Adults" (Press release). National Institute of Allergy and Infectious Diseases (NIAID). 24 January 2019. Retrieved 12 August 2019.
  7. ^ Public Domain This article incorporates text from this source, which is in the public domain: "FDA Approves First Treatment for Ebola Virus". U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.