| RND permease superfamily | |
|---|---|
 Crystallized AcrB: An HAE-RND subclass protein involved in drug and amphiphilic efflux | |
| Identifiers | |
| Symbol | RND_Permease |
| Pfam clan | CL0322 |
| ECOD | 5067.1.1 |
| TCDB | 2.A.6 |
| OPM superfamily | 16 |
| OPM protein | 2gif |
Resistance-nodulation-division (RND) family transporters are a category of bacterial efflux pumps, especially identified in Gram-negative bacteria and located in the cytoplasmic membrane, that actively transport substrates. The RND superfamily includes seven families: the heavy metal efflux (HME), the hydrophobe/amphiphile efflux-1 (gram-negative bacteria), the nodulation factor exporter family (NFE), the SecDF protein-secretion accessory protein family, the hydrophobe/amphiphile efflux-2 family, the eukaryotic sterol homeostasis family, and the hydrophobe/amphiphile efflux-3 family.[1] These RND systems are involved in maintaining homeostasis of the cell, removal of toxic compounds, and export of virulence determinants.[2] They have a broad substrate spectrum and can lead to the diminished activity of unrelated drug classes if over-expressed. The first reports of drug resistant bacterial infections were reported in the 1940s after the first mass production of antibiotics.[3] Most of the RND superfamily transport systems are made of large polypeptide chains.[4] RND proteins exist primarily in gram-negative bacteria but can also be found in gram-positive bacteria, archaea, and eukaryotes.
- ^ Tseng TT, Gratwick KS, Kollman J, Park D, Nies DH, Goffeau A, Saier MH (August 1999). "The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins". Journal of Molecular Microbiology and Biotechnology. 1 (1): 107–25. PMID 10941792.
- ^ Coyne S, Rosenfeld N, Lambert T, Courvalin P, Périchon B (October 2010). "Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii". Antimicrobial Agents and Chemotherapy. 54 (10): 4389–93. doi:10.1128/AAC.00155-10. PMC 2944555. PMID 20696879.
- ^ Routh, Mathew David, "Structure, function, and regulation of multidrug export proteins among the RND superfamily in Gram-negative bacteria" (2010). Graduate Theses and Dissertations. Paper 11401. http://lib.dr.iastate.edu/etd/11401
- ^ "2.A.6 The Resistance-Nodulation-Cell Division (RND) Superfamily". Transporter Classification Database.