Reston virus

Reston ebolavirus
An artificially colored transmission electron micrograph of the Reston virus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Filoviridae
Genus: Ebolavirus
Species:
Reston ebolavirus
Synonyms

Reston virus (RESTV)

Reston virus (RESTV) is one of six known viruses within the genus Ebolavirus. Reston virus causes Ebola virus disease in non-human primates; out of all 6 ebolaviruses, it is one of the only two not known to cause disease in humans, but has caused asymptomatic infections.[1][2][3] Reston virus was first described in 1990 as a new "strain" of Ebola virus (EBOV).[4] It is the single member of the species Reston ebolavirus, which is included into the genus Ebolavirus, family Filoviridae, order Mononegavirales.[5] Reston virus is named after Reston, Virginia, US, where the virus was first discovered.

RESTV was discovered in crab-eating macaques from Hazleton Laboratories (now Labcorp Drug Development) in 1989. This attracted significant media attention due to Reston's location in the Washington metropolitan area and the lethality of a closely related Ebola virus. Despite its status as a level-4 organism, Reston virus is non-pathogenic to humans, though hazardous to monkeys;[6][7] the perception of its lethality was compounded by the monkey's coinfection with Simian hemorrhagic fever virus (SHFV).[8] Despite ongoing research, the determinants for lack of human pathogenicity are yet to be discovered.[9]

  1. ^ Spickler, Anna. "Ebolavirus and Marburgvirus Infections" (PDF).
  2. ^ "About Ebola Virus Disease". CDC. Retrieved 18 October 2014.
  3. ^ "Years of Ebola Virus Disease Outbreaks | 2014-2016 Outbreak West Africa | History | Ebola (Ebola Virus Disease) | CDC". 2018-11-09.
  4. ^ Geisbert, T. W.; Jahrling, P. B. (1990). "Use of immunoelectron microscopy to show Ebola virus during the 1989 United States epizootic". Journal of Clinical Pathology. 43 (10): 813–816. doi:10.1136/jcp.43.10.813. PMC 502829. PMID 2229429.
  5. ^ Kuhn, Jens H.; Becker, Stephan; Ebihara, Hideki; Geisbert, Thomas W.; Johnson, Karl M.; Kawaoka, Yoshihiro; Lipkin, W. Ian; Negredo, Ana I; et al. (2010). "Proposal for a revised taxonomy of the family Filoviridae: Classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–103. doi:10.1007/s00705-010-0814-x. PMC 3074192. PMID 21046175.
  6. ^ Special Pathogens Branch CDC (2008-01-14). "Known Cases and Outbreaks of Ebola Hemorrhagic Fever". Centers for Disease Control and Prevention. Archived from the original on 2008-08-29. Retrieved 2008-08-02.
  7. ^ McCormick & Fisher-Hoch 1999, p. 300
  8. ^ McCormick & Fisher-Hoch 1999, pp. 307–309
  9. ^ Cantoni, Diego (December 28, 2016). "Risks Posed by Reston, the Forgotten Ebolavirus". mSphere. 1 (6). doi:10.1128/mSphere.00322-16. PMC 5196033. PMID 28066813.