Retinoblastoma-like protein 2

RBL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4XI9, 5C1D
Identifiers
Aliases	RBL2, P130, Rb2, retinoblastoma-like 2, RB transcriptional corepressor like 2, BRUWAG
External IDs	OMIM: 180203; MGI: 105085; HomoloGene: 4098; GeneCards: RBL2; OMA:RBL2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	53,491,648 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	91,850,472 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; superficial temporal artery; ; epithelium of nasopharynx; ; Achilles tendon; ; lymph node; ; cardia; ; tonsil; ; body of pancreas; ; pylorus; ; mucosa of paranasal sinus;
	Top expressed in
	parotid gland; ; muscle of thigh; ; spermatid; ; saccule; ; medial head of gastrocnemius muscle; ; submandibular gland; ; stroma of bone marrow; ; temporal muscle; ; triceps brachii muscle; ; thymus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; promoter-specific chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific;
Cellular component	nucleolus; extracellular exosome; nucleus; transcription regulator complex; nucleoplasm; cytosol; chromatin;
Biological process	regulation of transcription by RNA polymerase II; regulation of cell cycle; cell cycle; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of lipid kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; chromatin organization; regulation of mitotic cell cycle; cell differentiation; regulation of cell division; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	5934
	19651
	ENSG00000103479
	ENSMUSG00000031666
	Q08999
	Q64700
	NM_005611; NM_001323608; NM_001323609; NM_001323610; NM_001323611
	NM_001282000; NM_001282001; NM_011250
	NP_001310537; NP_001310538; NP_001310539; NP_001310540; NP_005602
	NP_001268929; NP_001268930; NP_035380
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103479 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031666 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A (Sep 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene. 8 (9): 2561–6. PMID 8361765.
^ Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (May 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4629–32. Bibcode:1996PNAS...93.4629B. doi:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103479 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031666 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8361765-5] Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A (Sep 1993). "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene. 8 (9): 2561–6. PMID 8361765.

[pmid8643454-6] Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (May 1996). "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4629–32. Bibcode:1996PNAS...93.4629B. doi:10.1073/pnas.93.10.4629. PMC 39329. PMID 8643454.

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