Retinoic acid receptor alpha

RARA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DKF, 1DSZ, 3A9E, 3KMR, 3KMZ, 4DQM, 5K13
Identifiers
Aliases	RARA, NR1B1, RAR, retinoic acid receptor alpha, RARalpha
External IDs	OMIM: 180240; MGI: 97856; HomoloGene: 20262; GeneCards: RARA; OMA:RARA - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 40,309,180 bp[1] End 40,357,643 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 62.76 cM Start 98,818,644 bp[2] End 98,865,768 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lactiferous duct monocyte granulocyte blood gallbladder right lung left uterine tube upper lobe of left lung tibial arteries canal of the cervix Top expressed in granulocyte genital tubercle tail of embryo lip yolk sac spermatocyte neural layer of retina spermatid molar female urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function retinoic acid binding transcription corepressor activity protein domain specific binding DNA-binding transcription factor activity nuclear receptor activity mRNA 5'-UTR binding signaling receptor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding retinoic acid-responsive element binding transcription factor binding metal ion binding steroid hormone receptor activity enzyme binding zinc ion binding protein binding DNA binding sequence-specific DNA binding transcription coactivator activity protein kinase A binding protein kinase B binding translation repressor activity, mRNA regulatory element binding alpha-actinin binding protein heterodimerization activity chromatin DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific histone deacetylase binding transcription cis-regulatory region binding nuclear receptor coactivator activity signaling receptor activity Cellular component cytoplasm actin cytoskeleton perinuclear region of cytoplasm neuron projection nucleus cell surface nucleoplasm soma dendrite cytosol RNA polymerase II transcription regulator complex Biological process growth plate cartilage development germ cell development cellular response to retinoic acid ureteric bud development positive regulation of interleukin-5 production prostate gland development limb development apoptotic cell clearance chondroblast differentiation regulation of granulocyte differentiation protein phosphorylation response to vitamin A face development spermatogenesis response to ethanol negative regulation of cell population proliferation steroid hormone mediated signaling pathway regulation of apoptotic process response to cytokine negative regulation of translation regulation of transcription, DNA-templated negative regulation of cell differentiation negative regulation of gene expression transcription, DNA-templated cellular response to estrogen stimulus positive regulation of transcription, DNA-templated positive regulation of cell cycle regulation of myelination positive regulation of neuron differentiation negative regulation of tumor necrosis factor production transcription initiation from RNA polymerase II promoter trachea cartilage development glandular epithelial cell development male gonad development negative regulation of cartilage development response to retinoic acid negative regulation of granulocyte differentiation multicellular organism growth female pregnancy negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II positive regulation of interleukin-4 production regulation of synaptic plasticity outflow tract septum morphogenesis negative regulation of transcription, DNA-templated negative regulation of interferon-gamma production response to estradiol negative regulation of translational initiation embryonic camera-type eye development positive regulation of interleukin-13 production neural tube closure positive regulation of binding retinoic acid receptor signaling pathway positive regulation of gene expression Sertoli cell fate commitment positive regulation of cell population proliferation positive regulation of T-helper 2 cell differentiation ventricular cardiac muscle cell differentiation liver development cellular response to lipopolysaccharide bone development hippocampus development signal transduction positive regulation of transcription by RNA polymerase II multicellular organism development hormone-mediated signaling pathway cell differentiation response to lipid gland development bone morphogenesis epithelium development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5914 19401 Ensembl ENSG00000131759 ENSMUSG00000037992 UniProt P10276 Q6I9R7 P11416 RefSeq (mRNA) NM_000964 NM_001024809 NM_001033603 NM_001145301 NM_001145302 NM_001176528 NM_001177302 NM_001177303 NM_009024 NM_001361954 RefSeq (protein) NP_000955 NP_001019980 NP_001138773 NP_001138774 NP_000955.1 NP_001138773.1 NP_001169999 NP_001170773 NP_001170774 NP_033050 NP_001348883 Location (UCSC) Chr 17: 40.31 – 40.36 Mb Chr 11: 98.82 – 98.87 Mb PubMed search [3] [4]
Wikidata
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Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1), is a nuclear receptor that in humans is encoded by the RARA gene.^[5][6]

NR1B1 is a gene with a protein product and has a chromosomal location of 17q21.2. RARA codes for the nuclear hormone receptor retinoic acid receptor, alpha subtype, a transcription factor. There are another two subtypes of RARs: beta and gamma subtypes.^[7][8]