Ribonuclease L

RNASEL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WDY, 4G8K, 4G8L, 4OAU, 4OAV
Identifiers
Aliases	RNASEL, PRCA1, RNS4, ribonuclease L
External IDs	OMIM: 180435; MGI: 1098272; HomoloGene: 8040; GeneCards: RNASEL; OMA:RNASEL - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 182,573,634 bp[1] End 182,589,256 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 G3 Start 153,625,172 bp[2] End 153,639,967 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid palpebral conjunctiva germinal epithelium epithelium of nasopharynx blood visceral pleura mucosa of paranasal sinus jejunal mucosa parietal pleura bronchial epithelial cell Top expressed in epithelium of small intestine left colon ileum granulocyte Rostral migratory stream intestinal villus stroma of bone marrow jejunum blood duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity rRNA binding metal ion binding endoribonuclease activity ribonuclease activity protein binding RNA binding nuclease activity ribonucleoprotein complex binding endonuclease activity hydrolase activity ATP binding identical protein binding Cellular component cytoplasm cytosol nuclear matrix mitochondrial matrix mitochondrion cellular component Biological process regulation of mRNA stability nucleic acid phosphodiester bond hydrolysis mRNA processing protein phosphorylation negative regulation of viral genome replication RNA phosphodiester bond hydrolysis defense response to virus type I interferon signaling pathway rRNA processing fat cell differentiation positive regulation of transcription by RNA polymerase II RNA phosphodiester bond hydrolysis, endonucleolytic regulation of type I interferon-mediated signaling pathway positive regulation of glucose import Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6041 24014 Ensembl ENSG00000135828 ENSMUSG00000066800 UniProt Q05823 Q05921 RefSeq (mRNA) NM_021133 NM_011882 RefSeq (protein) NP_066956 NP_036012 Location (UCSC) Chr 1: 182.57 – 182.59 Mb Chr 1: 153.63 – 153.64 Mb PubMed search [3] [4]
Wikidata
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Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral). RNase L is an enzyme that in humans is encoded by the RNASEL gene.^[5]

This gene encodes a component of the interferon-regulated 2'-5'oligoadenylate (2'-5'A) system that functions in the antiviral and antiproliferative roles of interferons. RNase L is activated by dimerization, which occurs upon 2'-5'A binding, and results in cleavage of all RNA in the cell. This can lead to activation of MDA5, an RNA helicase involved in the production of interferons.