Ripretinib

Ripretinib
Clinical data
Pronunciationrip re' ti nib
Trade namesQinlock
Other namesDCC-2618
AHFS/Drugs.comMonograph
MedlinePlusa620035
License data
Pregnancy
category
  • AU: D[1]
  • Use should be avoided
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
  • 3-{4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-1-phenylurea
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H21BrFN5O2
Molar mass510.367 g·mol−1
3D model (JSmol)
  • CCN1C(=O)C(=CC2=C1C=C(NC)N=C2)C1=C(Br)C=C(F)C(NC(=O)NC2=CC=CC=C2)=C1
  • InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)
  • Key:CEFJVGZHQAGLHS-UHFFFAOYSA-N

Ripretinib, sold under the brand name Qinlock, is a medication for the treatment of adults with advanced gastrointestinal stromal tumor (GIST), a type of tumor that originates in the gastrointestinal tract.[3][4] It is taken by mouth.[3][4] Ripretinib inhibits the activity of the kinases KIT and PDGFRA, which helps keep cancer cells from growing.[4]

The most common side effects include alopecia (hair loss), fatigue, nausea, abdominal pain, constipation, myalgia (muscle pain), diarrhea, decreased appetite, palmar-plantar erythrodysesthesia syndrome (a skin reaction in the palms and soles) and vomiting.[4][5][6]

Ripretinib was approved for medical use in the United States in May 2020,[3][4] in Australia in July 2020,[1] and in the European Union in November 2021.[5] Ripretinib is the first new drug specifically approved in the United States as a fourth-line treatment for advanced gastrointestinal stromal tumor (GIST).

  1. ^ a b c "Qinlock Australian Prescription Medicine Decision Summary". Therapeutic Goods Administration (TGA). 21 July 2020. Retrieved 17 August 2020.
  2. ^ "Summary Basis of Decision (SBD) for Qinlock". Health Canada. 23 October 2014. Retrieved 29 May 2022.
  3. ^ a b c d "Qinlock- ripretinib tablet". DailyMed. Retrieved 13 February 2022.
  4. ^ a b c d e f "FDA Approves First Drug for Fourth-Line Treatment of Advanced Gastrointestinal Stromal Tumors". U.S. Food and Drug Administration (FDA) (Press release). 15 May 2020. Retrieved 15 May 2020. Public Domain This article incorporates text from this source, which is in the public domain.
  5. ^ a b c Cite error: The named reference Qinlock EPAR was invoked but never defined (see the help page).
  6. ^ Cite error: The named reference FDA snapshot was invoked but never defined (see the help page).