Ritodrine

Ritodrine
Clinical data
Pronunciation/ˈraɪtoʊdriːn/ RY-toh-dreen
Trade namesPre-Par, Utopar, Yutopar
Other namesDU-21220; 4-Hydroxy-β-hydroxy-N-(4-hydroxyphenylethyl)amphetamine; N-(4-Hydroxyphenylethyl)-4-hydroxynorephedrine
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Oral (tablets), parenteral (IV)
ATC code
Legal status
Legal status
  • US: Discontinued
Pharmacokinetic data
Protein binding~56%
MetabolismHepatic, metabolites are inactive[1]
Elimination half-life1.7–2.6 hours
Identifiers
  • 4-[2-[[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.043.512 Edit this at Wikidata
Chemical and physical data
FormulaC17H21NO3
Molar mass287.359 g·mol−1
3D model (JSmol)
  • O[C@H](c1ccc(O)cc1)[C@@H](NCCc2ccc(O)cc2)C
  • InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1 checkY
  • Key:IOVGROKTTNBUGK-SJCJKPOMSA-N checkY
  (verify)

Ritodrine, sold under the brand name Yutopar, is a tocolytic drug used to stop premature labor.[2][3] This drug has been removed from the US market, according to FDA Orange Book. It was available in oral tablets or as an injection and was typically used as the hydrochloride salt.

The drug acts as a selective β2-adrenergic receptor agonist.[4]

It was first approved for medical use in the United States in 1984.[5]

  1. ^ Finkelstein BW (1981). "Ritodrine (Yutopar, Merrell Dow Pharmaceuticals Inc.)". Drug Intelligence & Clinical Pharmacy. 15 (6): 425–33. doi:10.1177/106002808101500601. S2CID 75942075.
  2. ^ Yaju Y, Nakayama T (November 2006). "Effectiveness and safety of ritodrine hydrochloride for the treatment of preterm labour: a systematic review". Pharmacoepidemiol Drug Saf. 15 (11): 813–822. doi:10.1002/pds.1317. PMID 16981213.
  3. ^ Li X, Zhang Y, Shi Z (February 2005). "Ritodrine in the treatment of preterm labour: a meta-analysis" (PDF). The Indian Journal of Medical Research. 121 (2): 120–7. PMID 15756046. Archived from the original (PDF) on 2019-08-25. Retrieved 2008-10-05.
  4. ^ Mangrella M, Torella M, Russo F, Rossi F, Piucci B, Cantoni V (June 1999). "[Pharmacology of ritodrine]". Minerva Ginecol (in Italian). 51 (6): 233–244. PMID 10479875.
  5. ^ Cite error: The named reference KleemannKutscher2022 was invoked but never defined (see the help page).