Robert Griffin may refer to:
- Robert Griffin (actor) (1902–1960), American film and television actor
- Robert Griffin (baseball) (fl. 1931), American baseball player
- Robert Griffin (offensive lineman) (born 1989), American football offensive lineman
- Robert Griffin III (born 1990), American football quarterback
- Robert F. Griffin (1925–1999), American Roman Catholic priest
- Robert G. Griffin (born 1942), professor of chemistry
- Bob Griffin (basketball) (Robert J. Griffin, born 1950), American-Israeli professional basketball player and professor of English Literature
- Robert P. Griffin (1923–2015), United States senator
- Robert U. Griffin, jazz trombonist