Roderick Macdonald may refer to:
- Roderick MacDonald (musician), principal trumpet of the Leipzig Gewandhaus Orchestra
- Roderick Macdonald, Lord Uist (born 1951), Scottish judge
- Roddy (R.S.) MacDonald (Roderick S. MacDonald, born 1956), Scottish pipe major and music composer previously based in Australia
- Roderick Macdonald (politician) (1840–1894), British Member of Parliament for Ross and Cromarty, 1885–1892
- Roderick A. Macdonald (1948–2014), Canadian legal scholar
- Roderick Charles MacDonald (1885–1978), merchant and politician in British Columbia, Canada
- Roderick Douglas Macdonald (1921–2001), Royal Navy admiral
- Roderick Lewis Macdonald (born 1957), Scottish Labour politician, Member of the Scottish Parliament (MSP) for North East Scotland 2011–2021