Romidepsin

Romidepsin
Skeletal formula of romidepsin
Clinical data
Trade namesIstodax
Other namesFK228; FR901228; Istodax
MedlinePlusa610005
License data
Routes of
administration		Intravenous infusion
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNot applicable (IV only)
Protein binding92–94%
MetabolismLiver (mostly CYP3A4-mediated)
Elimination half-life3 hours
Identifiers
  • (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.211.884 Edit this at Wikidata
Chemical and physical data
FormulaC24H36N4O6S2
Molar mass540.69 g·mol−1
3D model (JSmol)
  • C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C
  • InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1
  • Key:OHRURASPPZQGQM-GCCNXGTGSA-N
 ☒NcheckY (what is this?)  (verify)

Romidepsin, sold under the brand name Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs). Romidepsin is a natural product obtained from the bacterium Chromobacterium violaceum, and works by blocking enzymes known as histone deacetylases, thus inducing apoptosis.[2] It is sometimes referred to as depsipeptide, after the class of molecules to which it belongs. Romidepsin is branded and owned by Gloucester Pharmaceuticals, a part of Celgene.[3]

  1. ^ "Romidepsin-MSN, Romidepsin-Reach (Reach Pharmaceuticals Pty Ltd)". Therapeutic Goods Administration (TGA). 13 January 2023. Archived from the original on 18 March 2023. Retrieved 29 April 2023.
  2. ^ Cite error: The named reference NCI was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Gloucester was invoked but never defined (see the help page).