Rosmantuzumab

Rosmantuzumab
Monoclonal antibody
Type?
SourceHumanized (from mouse)
TargetRSPO3
Clinical data
Other namesOMP-131R10
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6456H9954N1714O2048S46
Molar mass145825.36 g·mol−1

Rosmantuzumab (INN;[1] development code OMP-131R10) is a humanized monoclonal antibody designed for the treatment of cancer.[2][3][4]

This drug was developed by OncoMed Pharmaceuticals.[5]

  1. ^ World Health Organization (2016). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 115" (PDF). WHO Drug Information. 30 (2).
  2. ^ Katoh M (August 2018). "Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)". Int. J. Mol. Med. 42 (2): 713–725. doi:10.3892/ijmm.2018.3689. PMC 6034925. PMID 29786110.
  3. ^ Katoh M (November 2017). "Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)". Int. J. Oncol. 51 (5): 1357–1369. doi:10.3892/ijo.2017.4129. PMC 5642388. PMID 29048660.
  4. ^ Katoh M, Katoh M (September 2017). "Molecular genetics and targeted therapy of WNT-related human diseases (Review)". Int. J. Mol. Med. 40 (3): 587–606. doi:10.3892/ijmm.2017.3071. PMC 5547940. PMID 28731148.
  5. ^ Statement On A Nonproprietary Name Adopted By The USAN Council - Rosmantuzumab, American Medical Association.