Rotigotine

Rotigotine
Clinical data
Trade namesNeupro, Leganto
AHFS/Drugs.comMonograph
MedlinePlusa607059
License data
Pregnancy
category
  • AU: B3
Routes of
administration		Transdermal patch
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • BR: Class C1 (Other controlled substances)[1]
  • US: ℞-only
  • EU: Rx-only[2]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability37% (transdermal)
Protein binding92%
MetabolismLiver (CYP-mediated)
Elimination half-life5–7 hours
ExcretionUrine (71%), Feces (23%)
Identifiers
  • (S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8- tetrahydronaphthalen-1-ol
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.123.257 Edit this at Wikidata
Chemical and physical data
FormulaC19H25NOS
Molar mass315.48 g·mol−1
3D model (JSmol)
  • Oc1cccc3c1CCC(N(CCC)CCc2sccc2)C3
  • InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3 checkY
  • Key:KFQYTPMOWPVWEJ-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Rotigotine, sold under the brand name Neupro among others, is a dopamine agonist of the non-ergoline class of medications indicated for the treatment of Parkinson's disease and restless legs syndrome.[3][4] It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours.[3]

Like other dopamine agonists, rotigotine has been shown to possess antidepressant effects and may be useful in the treatment of depression as well.[5]

  1. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  2. ^ Cite error: The named reference Neupro EPAR was invoked but never defined (see the help page).
  3. ^ a b Chen JJ, Swope DM, Dashtipour K, Lyons KE (December 2009). "Transdermal rotigotine: a clinically innovative dopamine-receptor agonist for the management of Parkinson's disease". Pharmacotherapy. 29 (12): 1452–1467. doi:10.1592/phco.29.12.1452. PMID 19947805. S2CID 40466260.
  4. ^ Davies S (September 2009). "Rotigotine for restless legs syndrome". Drugs of Today. 45 (9): 663–668. doi:10.1358/dot.2009.45.9.1399952. PMID 19956807.
  5. ^ Bertaina-Anglade V, La Rochelle CD, Scheller DK (October 2006). "Antidepressant properties of rotigotine in experimental models of depression". European Journal of Pharmacology. 548 (1–3): 106–114. doi:10.1016/j.ejphar.2006.07.022. PMID 16959244.