The Royal Botanical Expedition to New Granada (Spanish: Expedición Botánica al Virreinato de Nueva Granada) took place between 1783 and 1816 in the territories of New Granada, covering present-day Colombia, Ecuador, Panama, Venezuela, Peru and northern Brazil and western Guyana.
The project was rejected twice before being finally approved in 1783 by King Charles III of Spain, and was headed by José Celestino Mutis, a Spanish priest, who was also a botanist, mathematician and teacher.