Ryanodine receptor 3

RYR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4ERV
Identifiers
Aliases	RYR3, RYR-3, ryanodine receptor 3
External IDs	OMIM: 180903; MGI: 99684; HomoloGene: 68151; GeneCards: RYR3; OMA:RYR3 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	33,866,121 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	113,047,441 bp
RNA expression pattern
	Top expressed in
	thoracic diaphragm; ; sural nerve; ; right hemisphere of cerebellum; ; caudate nucleus; ; putamen; ; right uterine tube; ; nucleus accumbens; ; right frontal lobe; ; body of uterus; ; gastrocnemius muscle;
	Top expressed in
	olfactory tubercle; ; lateral septal nucleus; ; medial dorsal nucleus; ; subiculum; ; mammillary body; ; nucleus accumbens; ; motor neuron; ; lateral geniculate nucleus; ; globus pallidus; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	ryanodine-sensitive calcium-release channel activity; calcium channel activity; calcium-release channel activity; calmodulin binding; ion channel activity; calcium-induced calcium release activity; calcium ion binding;
Cellular component	organelle membrane; integral component of membrane; membrane; intracellular membrane-bounded organelle; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; endoplasmic reticulum; perinuclear region of cytoplasm; plasma membrane; smooth endoplasmic reticulum; Z discdkac; cytoplasmic vesicle membrane; calcium channel complex; sarcolemma;
Biological process	cellular response to calcium ion; cellular response to magnesium ion; regulation of cardiac conduction; cellular calcium ion homeostasis; ion transport; ion transmembrane transport; calcium ion transmembrane transport; cellular response to caffeine; cellular response to ATP; protein homotetramerization; calcium ion transport; negative regulation of cytosolic calcium ion concentration; transmembrane transport; release of sequestered calcium ion into cytosol;
	Sources:Amigo / QuickGO
Orthologs
	6263
	20192
	ENSG00000198838
	ENSMUSG00000057378
	Q15413
	A2AGL3
	NM_001036; NM_001243996
	NM_177652; NM_001319156
	NP_001027; NP_001230925
	NP_001306085
	Wikidata
View/Edit Human	View/Edit Mouse

Ryanodine receptor 3 is one of a class of ryanodine receptors and a protein that in humans is encoded by the RYR3 gene.^[5] The protein encoded by this gene is both a calcium channel and a receptor for the plant alkaloid ryanodine. RYR3 and RYR1 control the resting calcium ion concentration in skeletal muscle.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198838 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057378 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sorrentino V, Giannini G, Malzac P, Mattei MG (Feb 1994). "Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization". Genomics. 18 (1): 163–5. doi:10.1006/geno.1993.1446. PMID 8276408.
^ Perez CF, López JR, Allen PD (March 2005). "Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle". Am. J. Physiol., Cell Physiol. 288 (3): C640–9. doi:10.1152/ajpcell.00407.2004. PMID 15548569. S2CID 30888541.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198838 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057378 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8276408-5] Sorrentino V, Giannini G, Malzac P, Mattei MG (Feb 1994). "Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization". Genomics. 18 (1): 163–5. doi:10.1006/geno.1993.1446. PMID 8276408.

[pmid15548569-6] Perez CF, López JR, Allen PD (March 2005). "Expression levels of RyR1 and RyR3 control resting free Ca2+ in skeletal muscle". Am. J. Physiol., Cell Physiol. 288 (3): C640–9. doi:10.1152/ajpcell.00407.2004. PMID 15548569. S2CID 30888541.

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