S-phase kinase-associated protein 1

SKP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FQV, 1FS1, 1FS2, 1LDK, 1P22, 2ASS, 2AST, 2E31, 2E32, 2OVP, 2OVQ, 2OVR, 3L2O, 3WSO, 4I6J, 5IBK
Identifiers
Aliases	SKP1, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, S-phase kinase associated protein 1
External IDs	OMIM: 601434; MGI: 103575; HomoloGene: 38775; GeneCards: SKP1; OMA:SKP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	134,176,964 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	52,137,685 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; right hemisphere of cerebellum; ; right frontal lobe; ; right testis; ; pons; ; left testis; ; Brodmann area 9; ; ganglionic eminence; ; right adrenal gland; ; C1 segment;
	Top expressed in
	vestibular membrane of cochlear duct; ; primary oocyte; ; olfactory epithelium; ; spermatocyte; ; spermatid; ; medial ganglionic eminence; ; secondary oocyte; ; facial motor nucleus; ; anterior horn of spinal cord; ; embryonic cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	cullin family protein binding; beta-catenin binding; ubiquitin protein ligase activity; protein binding; ubiquitin-protein transferase activity; protein domain specific binding;
Cellular component	cytoplasm; nucleoplasm; PcG protein complex; nucleus; cytosol; SCF ubiquitin ligase complex; Cul7-RING ubiquitin ligase complex; centrosome;
Biological process	ubiquitin-dependent protein catabolic process; histone H2A monoubiquitination; NIK/NF-kappaB signaling; G2/M transition of mitotic cell cycle; stress-activated MAPK cascade; protein ubiquitination; protein polyubiquitination; Wnt signaling pathway; SCF complex assembly; negative regulation of G2/M transition of mitotic cell cycle; maintenance of protein location in nucleus; cellular iron ion homeostasis; post-translational protein modification; interleukin-1-mediated signaling pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; viral process; regulation of mitotic cell cycle phase transition; stimulatory C-type lectin receptor signaling pathway; Fc-epsilon receptor signaling pathway; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6500
	21402
	ENSG00000113558
	ENSMUSG00000036309
	P63208
	Q9WTX5
	NM_170679; NM_006930
	NM_011543
	NP_008861; NP_733779
	NP_035673
	Wikidata
View/Edit Human	View/Edit Mouse

S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.^[5]^[6]^[7]

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis.^[8] The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036309 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang H, Kobayashi R, Galaktionov K, Beach D (October 1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase". Cell. 82 (6): 915–25. doi:10.1016/0092-8674(95)90271-6. PMID 7553852. S2CID 16325791.
^ Demetrick DJ, Zhang H, Beach DH (July 1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)". Cytogenet Cell Genet. 73 (1–2): 104–7. doi:10.1159/000134318. PMID 8646875.
^ "Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)".
^ Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. PMID 8706131. S2CID 18387009.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036309 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7553852-5] Zhang H, Kobayashi R, Galaktionov K, Beach D (October 1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase". Cell. 82 (6): 915–25. doi:10.1016/0092-8674(95)90271-6. PMID 7553852. S2CID 16325791.

[pmid8646875-6] Demetrick DJ, Zhang H, Beach DH (July 1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)". Cytogenet Cell Genet. 73 (1–2): 104–7. doi:10.1159/000134318. PMID 8646875.

[entrez-7] "Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)".

[Bai-8] Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. PMID 8706131. S2CID 18387009.

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