S100A9

S100A9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1IRJ, 1XK4, 4GGF, 4XJK
Identifiers
Aliases	S100A9, 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14, S100 calcium binding protein A9, S100-A9
External IDs	OMIM: 123886; MGI: 1338947; HomoloGene: 2227; GeneCards: S100A9; OMA:S100A9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,357,854 bp[1] End 153,361,023 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.91 cM Start 90,599,939 bp[2] End 90,603,028 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte periodontal fiber bone marrow oral cavity mucosa of pharynx gums gingival epithelium bone marrow cells trabecular bone Top expressed in granulocyte tibiofemoral joint ankle joint femur body of femur fetal liver hematopoietic progenitor cell spleen blood vestibular membrane of cochlear duct human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding microtubule binding zinc ion binding signal transducer activity metal ion binding Toll-like receptor 4 binding antioxidant activity protein binding RAGE receptor binding arachidonic acid binding Cellular component membrane plasma membrane extracellular exosome cytoskeleton nucleus extracellular matrix extracellular space nucleoplasm cytosol cell junction secretory granule lumen cytoplasm extracellular region collagen-containing extracellular matrix Biological process peptidyl-cysteine S-trans-nitrosylation positive regulation of inflammatory response chemokine production immune system process cellular oxidant detoxification cell-cell signaling cytokine production leukocyte migration involved in inflammatory response neutrophil chemotaxis defense response to fungus chemotaxis sequestering of zinc ion neutrophil aggregation positive regulation of cell growth defense response to bacterium positive regulation of NF-kappaB transcription factor activity regulation of inflammatory response innate immune response inflammatory response activation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of intrinsic apoptotic signaling pathway regulation of cytoskeleton organization apoptotic process autophagy toll-like receptor signaling pathway antimicrobial humoral response neutrophil degranulation positive regulation of neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6280 20202 Ensembl ENSG00000163220 ENSMUSG00000056071 UniProt P06702 P31725 RefSeq (mRNA) NM_002965 NM_001281852 NM_009114 RefSeq (protein) NP_002956 NP_001268781 NP_033140 Location (UCSC) Chr 1: 153.36 – 153.36 Mb Chr 3: 90.6 – 90.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

S100 calcium-binding protein A9 (S100A9) also known as migration inhibitory factor-related protein 14 (MRP14) or calgranulin B is a protein that in humans is encoded by the S100A9 gene.^[5]

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.