S1PR3

S1PR3
Identifiers
Aliases	S1PR3, EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	OMIM: 601965; MGI: 1339365; HomoloGene: 3829; GeneCards: S1PR3; OMA:S1PR3 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	89,005,155 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	51,576,833 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; decidua; ; cardiac muscle tissue of right atrium; ; ventricular zone; ; right ventricle; ; right coronary artery; ; left coronary artery; ; tail of epididymis; ; Descending thoracic aorta; ; superficial temporal artery;
	Top expressed in
	internal carotid artery; ; molar; ; left lung lobe; ; external carotid artery; ; dermis; ; epithelium of lens; ; fossa; ; body of femur; ; lumbar spinal ganglion; ; abdominal wall;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; lipid binding; integrin binding; sphingosine-1-phosphate receptor activity; G protein-coupled receptor activity; protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	Notch signaling pathway; signal transduction; anatomical structure morphogenesis; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of establishment of endothelial barrier; positive regulation of cell population proliferation; sphingosine-1-phosphate receptor signaling pathway; regulation of interleukin-1 beta production; cytokine production; inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	1903
	13610
	ENSG00000213694
	ENSMUSG00000067586
	Q99500
	Q9Z0U9
	NM_005226
	NM_010101
	NP_005217
	NP_034231
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₃.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213694 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067586 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213694 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067586 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: S1PR3 sphingosine-1-phosphate receptor 3".

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