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| Surface Antigen 1 (SAG1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the immunodominant epitope displayed by the Surface Antigen 1 (SAG1) of Toxoplasma gondii complexed to a monoclonal antibody. | |||||||||
| Identifiers | |||||||||
| Symbol | SAG | ||||||||
| Pfam | PF04092 | ||||||||
| InterPro | IPR007226 | ||||||||
| SCOP2 | 1kzq / SCOPe / SUPFAM | ||||||||
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In molecular biology, the SAG1 protein domain is an example of a group of glycosylphosphatidylinositol (GPI)-linked proteins named SRSs (SAG1 related sequence).[1] SAG1 is found on the surface of a protozoan parasite Toxoplasma gondii. This parasite infects almost any warm-blooded vertebrate. The surface of T. gondii is coated with a family of developmentally regulated glycosylphosphatidylinositol (GPI)-linked proteins (SRSs), of which SAG1 is the prototypic member.[2]
- ^ He XL, Grigg ME, Boothroyd JC, Garcia KC (2002). "Structure of the immunodominant surface antigen from the Toxoplasma gondii SRS superfamily". Nat Struct Biol. 9 (8): 606–11. doi:10.1038/nsb819. PMID 12091874. S2CID 527217.
- ^ Cesbron-Delauw MF, Tomavo S, Beauchamps P, Fourmaux MP, Camus D, Capron A, et al. (1994). "Similarities between the primary structures of two distinct major surface proteins of Toxoplasma gondii". J Biol Chem. 269 (23): 16217–22. doi:10.1016/S0021-9258(17)33995-9. PMID 8206924.