SAPHO syndrome

SAPHO syndrome
Other namesSynovitis-acne-pustulosis-hyperostosis-osteitis syndrome
SpecialtyRheumatology Edit this on Wikidata

SAPHO syndrome includes a variety of inflammatory bone disorders that may be associated with skin changes. These diseases share some clinical, radiologic, and pathologic characteristics.

An entity initially known as chronic recurrent multifocal osteomyelitis was first described in 1972.[1] Subsequently, in 1978,[2] several cases of were associated with blisters on the palms and soles (palmoplantar pustulosis). Since then, a number of associations between skin conditions and osteoarticular disorders have been reported under a variety of names, including sternocostoclavicular hyperostosis, pustulotic arthro-osteitis, and acne-associated spondyloarthropathy. The term SAPHO (an acronym for synovitis, acne, pustulosis, hyperostosis, osteitis) was coined in 1987[3] to represent this spectrum of inflammatory bone disorders that may or may not be associated with dermatologic pathology.

  1. ^ Giedion A, Holthusen W, Masel LF, Vischer D (1972). "Subacute and chronic "symmetrical" osteomyelitis". Annals of Radiology. 15 (15): 329–42. PMID 4403064.
  2. ^ Bjorksten B, Gustavson KH, Eriksson B, et al. (1978). "Chronic recurrent multifocal osteomyelitis and pustulosis palmoplantaris". Journal of Pediatrics. 93 (2): 227–31. doi:10.1016/S0022-3476(78)80501-0. PMID 671154.
  3. ^ Chamot AM, Benhamou CL, Kahn MF, Beraneck L, Kaplan G, Prost A (1987). "Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases". Revue du Rhumatisme et des Maladies Osteo-Articulaires. 54 (3): 187–96. PMID 2954204.