SCN2B

SCN2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FEB, 5FDY
Identifiers
Aliases	SCN2B, ATFB14, sodium voltage-gated channel beta subunit 2
External IDs	OMIM: 601327; MGI: 106921; HomoloGene: 3373; GeneCards: SCN2B; OMA:SCN2B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,176,639 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,041,368 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; lateral nuclear group of thalamus; ; cerebellar cortex; ; cerebellar hemisphere; ; prefrontal cortex; ; right hemisphere of cerebellum; ; cerebellar vermis; ; superior frontal gyrus; ; primary visual cortex; ; right frontal lobe;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; lateral geniculate nucleus; ; olfactory tubercle; ; superior colliculus; ; medial geniculate nucleus; ; habenula; ; lateral septal nucleus; ; lateral hypothalamus; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	voltage-gated sodium channel activity involved in cardiac muscle cell action potential; sodium channel regulator activity; sodium channel activity; voltage-gated sodium channel activity; voltage-gated ion channel activity;
Cellular component	integral component of membrane; voltage-gated sodium channel complex; membrane;
Biological process	chemical synaptic transmission; nervous system development; cardiac muscle cell action potential involved in contraction; sodium ion transport; sodium ion transmembrane transport; regulation of sodium ion transmembrane transporter activity; cardiac muscle contraction; regulation of heart rate by cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; membrane depolarization during cardiac muscle cell action potential; regulation of ion transmembrane transport; ion transport; response to pyrethroid;
	Sources:Amigo / QuickGO
Orthologs
	6327
	72821
	ENSG00000149575
	ENSMUSG00000070304
	O60939
	Q56A07
	NM_004588
	NM_001014761
	NP_004579
	NP_001014761
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel subunit beta-2 is a protein that in humans is encoded by the SCN2B gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149575 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070304 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.
^ "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149575 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070304 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10198179-5] Plummer NW, Meisler MH (May 1999). "Evolution and diversity of mammalian sodium channel genes". Genomics. 57 (2): 323–31. doi:10.1006/geno.1998.5735. PMID 10198179.

[entrez-6] "Entrez Gene: SCN2B sodium channel, voltage-gated, type II, beta".

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