SCN4B

SCN4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MZ2, 4MZ3
Identifiers
Aliases	SCN4B, ATFB17, LQT10, Navbeta4, sodium voltage-gated channel beta subunit 4
External IDs	OMIM: 608256; MGI: 2687406; HomoloGene: 18384; GeneCards: SCN4B; OMA:SCN4B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,152,888 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	45,065,450 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; spinal ganglia; ; putamen; ; right hemisphere of cerebellum; ; pons; ; caudate nucleus; ; lateral nuclear group of thalamus; ; primary visual cortex; ; Brodmann area 23; ; trigeminal ganglion;
	Top expressed in
	triceps brachii muscle; ; ankle; ; vastus lateralis muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; knee joint; ; digastric muscle; ; extraocular muscle; ; medial head of gastrocnemius muscle; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	sodium channel regulator activity; transmembrane transporter binding; sodium channel activity; voltage-gated ion channel activity; voltage-gated sodium channel activity involved in cardiac muscle cell action potential; voltage-gated sodium channel activity;
Cellular component	voltage-gated sodium channel complex; integral component of membrane; membrane; intercalated disc; intrinsic component of plasma membrane; plasma membrane;
Biological process	cardiac muscle contraction; sodium ion transmembrane transport; sodium ion transport; regulation of ion transmembrane transport; cardiac muscle cell action potential involved in contraction; ion transport; regulation of sodium ion transmembrane transporter activity; positive regulation of sodium ion transport; AV node cell action potential; regulation of heart rate by cardiac conduction; membrane depolarization during cardiac muscle cell action potential; regulation of ventricular cardiac muscle cell membrane repolarization;
	Sources:Amigo / QuickGO
Orthologs
	6330
	399548
	ENSG00000177098
	ENSMUSG00000046480
	Q8IWT1
	Q7M729
	NM_001142348; NM_001142349; NM_174934
	NM_001013390
	NP_001135820; NP_001135821; NP_777594
	NP_001013408
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium channel β-subunit 4, also known as SCN4B or Naβ4, is an auxiliary sodium channel subunit that can alter the kinetics of sodium channels.^[5] The protein is encoded by the SCN4B gene.^[6] Mutations in the SCN4B are associated with long QT syndrome.^[7]

SCN4B might additionally function as a cell adhesion molecule.^[8]^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177098 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046480 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.
^ "Entrez Gene: sodium channel".
^ Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.
^ Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.
^ Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177098 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046480 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Lewis, Amanda H.; Raman, Indira M. (2014-11-15). "Resurgent current of voltage-gated Na+ channels". The Journal of Physiology. 592 (22): 4825–4838. doi:10.1113/jphysiol.2014.277582. ISSN 1469-7793. PMC 4259529. PMID 25172941.

[entrez-6] "Entrez Gene: sodium channel".

[pmid17592081-7] Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusié-Luna MT, Makielski JC, Ackerman MJ (July 2007). "SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome". Circulation. 116 (2): 134–42. doi:10.1161/CIRCULATIONAHA.106.659086. PMC 3332546. PMID 17592081.

[pmid27216889-8] Shimizu, Hideaki (2016). "Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits". Scientific Reports. 6: 26618. Bibcode:2016NatSR...626618S. doi:10.1038/srep26618. PMC 4877568. PMID 27216889.

[pmid28655765-9] Shimizu, Hideaki (2017). "Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion". J Biol Chem. 27 (32): 13428–13440. doi:10.1074/jbc.M117.786509. PMC 5555201. PMID 28655765.

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