SCO-spondin

SSPOP
Identifiers
Aliases	SSPOP, SCO-spondin, SCO-spondin, pseudogene, SSPO
External IDs	OMIM: 617356; MGI: 2674311; HomoloGene: 45453; GeneCards: SSPOP; OMA:SSPOP - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	149,833,979 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	48,478,184 bp
Gene ontology
Molecular function	peptidase inhibitor activity;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of peptidase activity; cell adhesion; nervous system development; cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	23145
	243369
	ENSG00000197558
	ENSMUSG00000029797
	A2VEC9
	Q8CG65
	NM_198455
	NM_173428
	NP_940857
	NP_775604
	Wikidata
View/Edit Human	View/Edit Mouse

SCO-spondin is a protein that in humans is encoded by the SSPO gene.^[5]^[6]^[7] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197558 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029797 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5) (5): 1053–61. doi:10.1242/jcs.109.5.1053. PMID 8743952.
^ Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. S2CID 46625717.
^ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".
^ Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. S2CID 426154.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029797 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8743952-5] Gobron S, Monnerie H, Meiniel R, Creveaux I, Lehmann W, Lamalle D, Dastugue B, Meiniel A (May 1996). "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109. 109 ( Pt 5) (5): 1053–61. doi:10.1242/jcs.109.5.1053. PMID 8743952.

[pmid11008217-6] Gobron S, Creveaux I, Meiniel R, Didier R, Herbet A, Bamdad M, El Bitar F, Dastugue B, Meiniel A (November 2000). "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia. 32 (2): 177–91. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217. S2CID 46625717.

[entrez-7] "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)".

[pmid10197783-8] Gobron S, Creveaux I, Meiniel R, Didier R, Dastugue B, Meiniel A (January 1999). "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience. 88 (2): 655–64. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783. S2CID 426154.

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