SENP1

SENP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CKG, 2CKH, 2G4D, 2IY0, 2IY1, 2IYC, 2IYD, 2XPH, 2XRE
Identifiers
Aliases	SENP1, SuPr-2, SUMO1/sentrin specific peptidase 1, SUMO specific peptidase 1
External IDs	OMIM: 612157; MGI: 2445054; HomoloGene: 8731; GeneCards: SENP1; OMA:SENP1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	48,106,079 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	97,991,625 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; testicle; ; sperm; ; buccal mucosa cell; ; Achilles tendon; ; ventricular zone; ; bone marrow cells; ; ganglionic eminence;
	Top expressed in
	zygote; ; secondary oocyte; ; spermatocyte; ; spermatid; ; tail of embryo; ; ascending aorta; ; genital tubercle; ; aortic valve; ; Rostral migratory stream; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; cysteine-type peptidase activity; endopeptidase activity; protein binding; hydrolase activity; SUMO-specific endopeptidase activity; SUMO-specific protease activity;
Cellular component	cytoplasm; nuclear membrane; focal adhesion; nucleoplasm; nucleus;
Biological process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process; apoptotic signaling pathway; protein desumoylation; activation of cysteine-type endopeptidase activity involved in apoptotic process; protein sumoylation; positive regulation of transcription by RNA polymerase II; proteolysis; regulation of definitive erythrocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	29843
	223870
	ENSG00000079387
	ENSMUSG00000033075
	Q9P0U3
	P59110
	NM_001267594; NM_001267595; NM_014554
	NM_144851; NM_001379573
	NP_001254523; NP_001254524
	NP_659100; NP_001366502
	Wikidata
View/Edit Human	View/Edit Mouse

Sentrin-specific protease 1 is an enzyme that in humans is encoded by the SENP1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000079387 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033075 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gong L, Millas S, Maul GG, Yeh ET (Feb 2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". The Journal of Biological Chemistry. 275 (5): 3355–9. doi:10.1074/jbc.275.5.3355. PMID 10652325.
^ Bailey D, O'Hare P (Jan 2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1". The Journal of Biological Chemistry. 279 (1): 692–703. doi:10.1074/jbc.M306195200. PMID 14563852.
^ "Entrez Gene: SENP1 SUMO1/sentrin specific peptidase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000079387 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033075 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10652325-5] Gong L, Millas S, Maul GG, Yeh ET (Feb 2000). "Differential regulation of sentrinized proteins by a novel sentrin-specific protease". The Journal of Biological Chemistry. 275 (5): 3355–9. doi:10.1074/jbc.275.5.3355. PMID 10652325.

[pmid14563852-6] Bailey D, O'Hare P (Jan 2004). "Characterization of the localization and proteolytic activity of the SUMO-specific protease, SENP1". The Journal of Biological Chemistry. 279 (1): 692–703. doi:10.1074/jbc.M306195200. PMID 14563852.

[entrez-7] "Entrez Gene: SENP1 SUMO1/sentrin specific peptidase 1".

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