SERPINA12

SERPINA12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IF8, 4Y3K, 4Y40, 5EI0
Identifiers
Aliases	SERPINA12, OL-64, serpin family A member 12
External IDs	OMIM: 617471; MGI: 1915304; HomoloGene: 23588; GeneCards: SERPINA12; OMA:SERPINA12 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,517,844 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,010,702 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of thigh; ; skin of hip; ; skin of abdomen; ; testicle; ; nipple; ; human penis; ; vulva; ; right lobe of liver; ; right uterine tube;
	Top expressed in
	left lobe of liver; ; skin of external ear; ; lip; ; skin of back; ; umbilical cord; ; skin of abdomen; ; sexually immature organism; ; embryo; ; mucous cell of stomach; ; epidermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; plasma membrane; extracellular space;
Biological process	regulation of cholesterol metabolic process; negative regulation of gluconeogenesis; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of insulin receptor signaling pathway; regulation of triglyceride metabolic process; negative regulation of peptidase activity; negative regulation of lipid biosynthetic process; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	145264
	68054
	ENSG00000165953
	ENSMUSG00000041567
	Q8IW75
	Q7TMF5
	NM_001304461; NM_173850; NM_001382267
	NM_026535
	NP_001291390; NP_776249; NP_001369196
	NP_080811
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin A12 (OL-64, Vaspin, Visceral adipose-specific serpin, Ser A12) is a glycoprotein that is a class A member of the serine protease inhibitor (serpin) family.^[5] In humans, Serpin A12 is encoded by the SERPINA12 gene.^[6]

First discovered in 2005, Serpin A12 was highly expressed in white adipose tissue of Otsuka Long Evans Tokushima Fatty Rats at the same time that the rats' obesity and insulin plasma levels reached a peak, at around 30 weeks old. Eventually, it was found to be expressed in visceral and subcutaneous adipose tissue of obese humans, leading the protein to be linked with obesity, glucose metabolism, and insulin resistance.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165953 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041567 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kyrou I, Mattu HS, Chatha K, Randeva HS (2017). "Fat Hormones, Adipokines". Endocrinology of the Heart in Health and Disease. pp. 167–205. doi:10.1016/B978-0-12-803111-7.00007-5. ISBN 9780128031117.
^ ^a ^b "UniProtKB - Q8IW75 (SPA12_HUMAN)". UniProt. November 1, 2020. Retrieved Nov 1, 2020.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165953 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041567 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:1-5] Kyrou I, Mattu HS, Chatha K, Randeva HS (2017). "Fat Hormones, Adipokines". Endocrinology of the Heart in Health and Disease. pp. 167–205. doi:10.1016/B978-0-12-803111-7.00007-5. ISBN 9780128031117.

[:0-6] "UniProtKB - Q8IW75 (SPA12_HUMAN)". UniProt. November 1, 2020. Retrieved Nov 1, 2020.

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