SERPINB1

SERPINB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSERPINB1, EI, ELANH2, HEL57, LEI, M/NEI, MNEI, PI-2, PI2, HEL-S-27, serpin family B member 1
External IDsOMIM: 130135; MGI: 1913472; HomoloGene: 133768; GeneCards: SERPINB1; OMA:SERPINB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030666

NM_025429

RefSeq (protein)

NP_109591

NP_079705

Location (UCSC)Chr 6: 2.83 – 2.84 MbChr 13: 33.03 – 33.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[5][6][7]

MNEI (monocyte/neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000021355Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044734Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. Bibcode:1992PNAS...89.5635R. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927.
  6. ^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1".
  7. ^ a b Benarafa C, Remold-O'Donnell E (August 2005). "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. Bibcode:2005PNAS..10211367B. doi:10.1073/pnas.0502934102. PMC 1183561. PMID 16055559.