SGK3

SGK3
Identifiers
Aliases	SGK3, CISK, SGK2, SGKL, serum/glucocorticoid regulated kinase family member 3
External IDs	OMIM: 607591; MGI: 2182368; HomoloGene: 56582; GeneCards: SGK3; OMA:SGK3 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	66,862,022 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	9,971,070 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; corpus callosum; ; inferior ganglion of vagus nerve; ; mucosa of ileum; ; subthalamic nucleus; ; skin of arm; ; pars reticulata; ; jejunal mucosa; ; medulla oblongata; ; skin of hip;
	Top expressed in
	vestibular membrane of cochlear duct; ; retinal pigment epithelium; ; Epithelium of choroid plexus; ; molar; ; gastrula; ; granulocyte; ; hair follicle; ; endothelial cell of lymphatic vessel; ; cornea; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; sodium channel regulator activity; calcium channel regulator activity; kinase activity; potassium channel regulator activity; protein binding; phosphatidylinositol binding; chloride channel regulator activity; ATP binding; protein serine/threonine kinase activity;
Cellular component	recycling endosome; cytosol; endosome; early endosome; cytoplasmic vesicle;
Biological process	regulation of apoptotic process; intracellular signal transduction; regulation of cell migration; positive regulation of transporter activity; phosphorylation; protein phosphorylation; ion transmembrane transport; regulation of cell population proliferation; peptidyl-serine phosphorylation; regulation of DNA-binding transcription factor activity; regulation of cell growth; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand;
	Sources:Amigo / QuickGO
Orthologs
	23678
	170755
	ENSG00000104205
	ENSMUSG00000025915
	Q96BR1
	Q9ERE3
	NM_170709; NM_001033578; NM_013257
	NM_001037759; NM_133220; NM_177547
	NP_001191102; NP_001028750; NP_037389; NP_733827
	NP_001032848; NP_573483; NP_808215
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104205 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025915 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.
^ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
^ "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104205 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025915 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10585774-5] Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X, Zhao S (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics. 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774.

[pmid10548550-6] Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.

[entrez-7] "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3".

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