SGPL1

SGPL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Q6R
Identifiers
Aliases	SGPL1, S1PL, SPL, sphingosine-1-phosphate lyase 1, NPHS14
External IDs	OMIM: 603729; MGI: 1261415; HomoloGene: 2897; GeneCards: SGPL1; OMA:SGPL1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	70,881,184 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	60,983,482 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; gingival epithelium; ; sural nerve; ; ventricular zone; ; skin of arm; ; germinal epithelium; ; islet of Langerhans; ; secondary oocyte; ; epithelium of nasopharynx; ; ganglionic eminence;
	Top expressed in
	transitional epithelium of urinary bladder; ; olfactory epithelium; ; stroma of bone marrow; ; gastrula; ; decidua; ; lip; ; thymus; ; jejunum; ; granulocyte; ; skin of external ear;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; catalytic activity; lyase activity; pyridoxal phosphate binding; carboxy-lyase activity; sphinganine-1-phosphate aldolase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	fibroblast migration; roof of mouth development; luteinization; Leydig cell differentiation; estrogen metabolic process; androgen metabolic process; kidney development; ceramide metabolic process; regulation of multicellular organism growth; lipid metabolism; carboxylic acid metabolic process; skeletal system morphogenesis; sphingolipid biosynthetic process; post-embryonic development; fatty acid metabolic process; female gonad development; vasculogenesis; nitrogen compound metabolic process; spermatogenesis; apoptotic signaling pathway; platelet-derived growth factor receptor signaling pathway; face morphogenesis; apoptotic process; sphingolipid metabolic process; sphingolipid catabolic process; hemopoiesis; ameboidal-type cell migration;
	Sources:Amigo / QuickGO
Orthologs
	8879
	20397
	ENSG00000166224
	ENSMUSG00000020097
	O95470
	Q8R0X7
	NM_003901
	NM_009163; NM_001316673; NM_001316674
	NP_003892
	NP_001303602; NP_001303603; NP_033189
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166224 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020097 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.
^ Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. Bibcode:2006PNAS..10317384O. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.
^ "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166224 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020097 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9464245-5] Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. doi:10.1006/bbrc.1997.7993. PMID 9464245.

[pmid17090686-6] Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. Bibcode:2006PNAS..10317384O. doi:10.1073/pnas.0600050103. PMC 1859938. PMID 17090686.

[entrez-7] "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

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