SHANK1

SHANK1
Identifiers
Aliases	SHANK1, SPANK-1, SSTRIP, synamon, SH3 and multiple ankyrin repeat domains 1
External IDs	OMIM: 604999; MGI: 3613677; HomoloGene: 22949; GeneCards: SHANK1; OMA:SHANK1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	50,719,802 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,009,996 bp
RNA expression pattern
	Top expressed in
	anterior cingulate cortex; ; right frontal lobe; ; prefrontal cortex; ; amygdala; ; right hemisphere of cerebellum; ; primary visual cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; hippocampus proper; ; middle temporal gyrus;
	Top expressed in
	prefrontal cortex; ; primary motor cortex; ; temporal lobe; ; subiculum; ; cingulate gyrus; ; amygdala; ; lateral geniculate nucleus; ; piriform cortex; ; primary visual cortex; ; medial dorsal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	somatostatin receptor binding; SH3 domain binding; ankyrin repeat binding; scaffold protein binding; protein C-terminus binding; protein binding; synaptic receptor adaptor activity; identical protein binding; ionotropic glutamate receptor binding; signaling receptor complex adaptor activity; protein-containing complex binding;
Cellular component	cytoplasm; postsynaptic membrane; membrane; dendritic spine; synapse; excitatory synapse; intracellular anatomical structure; NMDA selective glutamate receptor complex; cell junction; dendrite; neuron projection; ionotropic glutamate receptor complex; postsynaptic density; cytosol; plasma membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse; neuron spine;
Biological process	cell differentiation; olfactory behavior; associative learning; neuromuscular process controlling balance; negative regulation of actin filament bundle assembly; positive regulation of dendritic spine development; nervous system development; regulation of AMPA receptor activity; dendritic spine morphogenesis; vocalization behavior; adult behavior; long-term memory; synapse maturation; positive regulation of excitatory postsynaptic potential; social behavior; habituation; determination of affect; righting reflex; protein localization to synapse; protein-containing complex assembly; postsynapse organization; synapse assembly; brain morphogenesis; synaptic assembly at neuromuscular junction; positive regulation of synaptic transmission, glutamatergic; long-term potentiation; postsynaptic density assembly;
	Sources:Amigo / QuickGO
Orthologs
	50944
	243961
	ENSG00000161681
	ENSMUSG00000038738
	Q9Y566
	D3YZU1
	NM_016148
	NM_001034115
	NP_057232
	NP_001029287
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161681 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038738 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (November 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". The Journal of Biological Chemistry. 274 (46): 32997–33001. doi:10.1074/jbc.274.46.32997. PMID 10551867.
^ "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000161681 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038738 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10551867-5] Zitzer H, Hönck HH, Bächner D, Richter D, Kreienkamp HJ (November 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". The Journal of Biological Chemistry. 274 (46): 32997–33001. doi:10.1074/jbc.274.46.32997. PMID 10551867.

[entrez-6] "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1".

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