SHC1

SHC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MIL, 1N3H, 1OY2, 1QG1, 1SHC, 1TCE, 2L1C, 4JMH, 4XWX, 5CZI
Identifiers
Aliases	SHC1, SHC, SHCA, SHC adaptor protein 1
External IDs	OMIM: 600560; MGI: 98296; HomoloGene: 7934; GeneCards: SHC1; OMA:SHC1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 154,962,298 bp[1] End 154,974,395 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.11 cM Start 89,325,750 bp[2] End 89,337,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium gallbladder smooth muscle tissue Descending thoracic aorta gastric mucosa anterior pituitary left uterine tube cartilage tissue right lobe of thyroid gland canal of the cervix Top expressed in lens tail of embryo granulocyte uterus genital tubercle lung yolk sac islet of Langerhans epiblast stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin-like growth factor receptor binding transmembrane receptor protein tyrosine kinase adaptor activity insulin receptor binding neurotrophin TRKA receptor binding ephrin receptor binding epidermal growth factor receptor binding receptor tyrosine kinase binding protein binding phospholipid binding epidermal growth factor binding phosphotyrosine residue binding Cellular component cytoplasm cytosol mitochondrial matrix mitochondrion Shc-EGFR complex plasma membrane Biological process actin cytoskeleton reorganization insulin receptor signaling pathway intracellular signal transduction epidermal growth factor receptor signaling pathway cellular response to growth factor stimulus MAPK cascade Fc-epsilon receptor signaling pathway heart development IRE1-mediated unfolded protein response regulation of cell population proliferation angiogenesis regulation of epidermal growth factor-activated receptor activity regulation of growth Ras protein signal transduction viral process leukocyte migration signal transduction ERBB2 signaling pathway axon guidance defense response to bacterium negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of ERK1 and ERK2 cascade cell-cell adhesion interleukin-15-mediated signaling pathway negative regulation of angiogenesis cytokine-mediated signaling pathway interleukin-2-mediated signaling pathway positive regulation of cell proliferation in bone marrow regulation of superoxide metabolic process positive regulation of cell population proliferation positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6464 20416 Ensembl ENSG00000160691 ENSMUSG00000042626 UniProt P29353 P98083 RefSeq (mRNA) NM_001130040 NM_001130041 NM_001202859 NM_003029 NM_183001 NM_001113331 NM_011368 RefSeq (protein) NP_001123512 NP_001123513 NP_001189788 NP_003020 NP_892113 NP_001106802 NP_035498 Location (UCSC) Chr 1: 154.96 – 154.97 Mb Chr 3: 89.33 – 89.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.^[5] SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.

SCOP classifies the 3D structure as belonging to the SH2 domain family.