SIAH2

SIAH2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5H9M
Identifiers
Aliases	SIAH2, hSiah2, siah E3 ubiquitin protein ligase 2
External IDs	OMIM: 602213; MGI: 108062; HomoloGene: 21053; GeneCards: SIAH2; OMA:SIAH2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	150,763,477 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	58,599,821 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; monocyte; ; ectocervix; ; right lobe of liver; ; blood; ; canal of the cervix; ; bone marrow; ; stromal cell of endometrium;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; seminiferous tubule; ; spermatid; ; olfactory epithelium; ; ankle joint; ; parotid gland; ; right kidney; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription corepressor activity; zinc ion binding; metal ion binding; protein binding; ubiquitin conjugating enzyme binding; transferase activity; ubiquitin-protein transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; soma; early endosome; neuron projection; nucleus;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; small GTPase mediated signal transduction; regulation of protein ubiquitination; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of apoptotic process; axon guidance; multicellular organism development; protein ubiquitination; cell cycle; negative regulation of canonical Wnt signaling pathway; apoptotic process; negative regulation of nucleic acid-templated transcription; protein polyubiquitination; protein deubiquitination; ubiquitin-dependent protein catabolic process; negative regulation of netrin-activated signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	6478
	20439
	ENSG00000181788
	ENSMUSG00000036432
	O43255
	Q06986
	NM_005067
	NM_009174
	NP_005058
	NP_033200
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181788 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036432 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER (October 1997). "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway". Genes & Development. 11 (20): 2701–14. doi:10.1101/gad.11.20.2701. PMC 316613. PMID 9334332.
^ "Entrez Gene: SIAH2 seven in absentia homolog 2 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181788 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036432 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9334332-5] Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER (October 1997). "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway". Genes & Development. 11 (20): 2701–14. doi:10.1101/gad.11.20.2701. PMC 316613. PMID 9334332.

[entrez-6] "Entrez Gene: SIAH2 seven in absentia homolog 2 (Drosophila)".

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