SIGLEC10

SIGLEC10
Identifiers
Aliases	SIGLEC10, PRO940, SIGLEC-10, SLG2, sialic acid binding Ig like lectin 10
External IDs	OMIM: 606091; MGI: 2443630; HomoloGene: 13228; GeneCards: SIGLEC10; OMA:SIGLEC10 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,417,803 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,067,782 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; appendix; ; spleen; ; oocyte; ; secondary oocyte; ; lymph node; ; buccal mucosa cell; ; right adrenal cortex;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; granulocyte; ; blood; ; subcutaneous adipose tissue; ; bone marrow; ; pharynx; ; morula; ; submandibular gland; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding; protein binding; phosphatase binding; SH2 domain binding;
Cellular component	integral component of membrane; extracellular region; membrane; plasma membrane;
Biological process	cell adhesion; adaptive immune response; immune system process; innate immune response; negative regulation of inflammatory response to wounding;
	Sources:Amigo / QuickGO
Orthologs
	89790
	243958
	ENSG00000142512
	ENSMUSG00000030468
	Q96LC7
	Q80ZE3
NM_001171156; NM_001171157; NM_001171158; NM_001171159; NM_001171160;
	NM_001171161; NM_033130; NM_001322105
	NM_172900; NM_001382486
NP_001164627; NP_001164628; NP_001164629; NP_001164630; NP_001164632;
	NP_001309034; NP_149121
	NP_766488; NP_001369415
	Wikidata
View/Edit Human	View/Edit Mouse

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene.^[5]^[6] Siglec-G is often referred to as the murine paralog of human Siglec-10 ^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142512 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030468 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (Apr 2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor". Biochem J. 355 (Pt 2): 489–97. doi:10.1042/0264-6021:3550489. PMC 1221762. PMID 11284738.
^ "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".
^ Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H (Nov 2018). "Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells". J. Clin. Invest. 128 (Pt 11): 4912–23. doi:10.1172/JCI120612. PMC 6205408. PMID 30130255.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142512 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030468 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11284738-5] Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (Apr 2001). "Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor". Biochem J. 355 (Pt 2): 489–97. doi:10.1042/0264-6021:3550489. PMC 1221762. PMID 11284738.

[entrez-6] "Entrez Gene: SIGLEC10 sialic acid binding Ig-like lectin 10".

[pmid30130255-7] Stanczak MA, Siddiqui SS, Trefny MP, Thommen DS, Boligan KF, von Gunten S, Tzankov A, Tietze L, Lardinois D, Heinzelmann-Schwarz V, von Bergwelt-Baildon M, Zhang W, Lenz HJ, Han Y, Amos CI, Syedbasha M, Egli A, Stenner F, Speiser DE, Varki A, Zippelius A, Läubli H (Nov 2018). "Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells". J. Clin. Invest. 128 (Pt 11): 4912–23. doi:10.1172/JCI120612. PMC 6205408. PMID 30130255.

[1]

[2]

[3]

[4]

[5]

[6]

[7]